摘要
目的:分析北京大学人民医院2015年万古霉素血药浓度监测情况,为临床个体化用药提供依据。方法:对进行万古霉素血药浓度监测的149例患者的一般资料、原患疾病、病原学检测结果、血药浓度、肾功能等临床资料进行统计分析。结果:患者万古霉素血药浓度监测率为13.26%,万古霉素血药谷浓度在10~20μg·m L^(-1)的患者占41.23%,治疗前后肾功能异常占比率分别为27.52%和30.87%。结论:北京大学人民医院万古霉素血药谷浓度总体正常,但仍有少部分患者血药浓度异常,可结合临床实际适当调整万古霉素用量。
Objective： To analyze therapeutic drug monitoring of vancomycin in our hospital at 2015, and to provide evidence for clinical individualized medication. Methods： Statistical analysis was conducted on general information, original illness, pathogen detection result, plasma concentration and renal function which derived from 149 cases of patients with blood concentration monitoring of vancomycin. Results： The therapeutic drug monitoring rate was 13.26%. The blood trough concentration during 10-20 μg·m L^（-1） accounted for 41.23%. Before and after treatment renal dysfunction rate were 27.52% and 30.87% respectively. Conclusion： Vancomycin therapeutic drug monitoring results were mainly normal in most of our patients our hospital, but there were still some aberrant testing results. The dosage of vancomycin should be adjusted according to clinical reality.
出处
《临床药物治疗杂志》
2016年第6期27-29,共3页
Clinical Medication Journal
基金
国家科技重大专项重大新药创制项目资助(2012ZX09303019)
关键词
万古霉素
血药浓度
监测
Vancomycin
serum concentration
monitoring
