摘要
慢性自发性荨麻疹为皮肤科常见疾病,其发病机制复杂,治疗效果欠佳。抗组胺药物为一线用药,应首选第二代非镇静H1抗组胺药物,且剂量加倍可有效缓解难治性慢性荨麻疹症状。联合使用白三烯受体拮抗剂和抗组胺药物对难治性慢性荨麻疹疗效显著。环孢素仅在一线、二线药物治疗失败时应用,使用时间不宜超过3个月。奥马珠单抗可有效控制慢性自发性荨麻疹症状,推荐剂量为300 mg/4周,但应注意其不良反应。
Chronic spontaneous urticaria is a common cutaneous disorder, but the underlying pathogenesis is complex and the efficacy of therapy is unsatisfactory. The first-line therapy for this disorder is antihistamine, of which the second-generation non-sedative products should be given as priority and the first-generation should be avoided. In addition, doubling the dosage can efficaciously relieve urticarial symptoms. Leukotriene receptor antagonist combined with antihistamine has remarkable efficacy for the treatment of urticaria. Cyclosporin can be only administered when the first-line and second-line treatments failed, and the duration should be no more than three months. Omalizumab can effectively control symptoms of chronic spontaneous urticaria under the recom- mended dose of 300 mg per four weeks; however, attention should be paid to its side effects closely.
出处
《中华临床免疫和变态反应杂志》
2016年第4期407-411,共5页
Chinese Journal of Allergy & Clinical Immunology
关键词
荨麻疹
慢性
自发性
药物
治疗
urticaria
chronic
spontaneous
pharmacotherapy
