摘要
NLRP3属于炎性小体的一员,由于能被多种类型的病原体或危险信号所激活,NLRP3炎小体在多种疾病过程中发挥关键作用,越来越受到关注,因此,调控NLRP3炎性小体表达成为药物研究领域的新热点。目前,新调控NLRP3炎性小体物质的发现主要通过合成和天然产物这两种途径。通过查阅CNKI、Pubmed等数据库,对调控NLRP3炎性小体的天然产物研究进展进行综述,旨在为抗炎药物的研究提供参考。
NLRP3,belonging to one of the inflammasomes,can be activated by pathogens of various diseases or danger signals and hence plays an important role in the onset and development of various diseases including diabetes. Inhibition of NLRP3 inflammasome expression has since turned to be a hot topic for medicinal research in the world. The inhibiting substances of the NLRP3 inflammasome can be found via either synthetic or natural method. The research progress in natural inhibition of the NLRP3 inflammasome were reviewed from some databases such as CNKI,Pubmed,etc. More than 20 compounds were found to inhibit the NLRP2 inflammasome,of which flavonoids,terpenoids,and alkaloids were described. This review might provide scientific evidence for developing new drugs in the future.
作者
金燕
李祎莹
董琳
吴悠楠
张小坡
JIN Yan LI Yiying DONG Lin WU YounanI ZHANG Xiaopo(School of Pharmaceutical Science, Hainan Medical University, Haikou, Hainan 571199 School of Basic Medical Science, Hainan Medical University, Haikou, Hainan 571199)
出处
《热带生物学报》
2016年第4期517-521,共5页
Journal of Tropical Biology
基金
国家自然科学基金(81560696)
