摘要
通过中国知网、万方、Web of Science数据库,以"香附"、"艾叶"、"子宫"、"原发性痛经"、"镇痛"、"Cyperus rotundus L."、"Artemisia argyi Lévl.et Vant."、"Primary Dysmenorrhea"和"Uterus"为关键词,系统检索、整理和归纳了1977~2016年间与"原发性痛经发病机制、香附与艾叶治疗痛经的作用机理"相关的实验研究文献45篇,并对其进行分析和综述。结果显示,原发性痛经主要与PGs、β-EP、5-HT、血管加压素、Ca2+和NO等生物因子分泌水平相关。香附与艾叶各部位对镇痛均有活性作用,但其活性强弱有一定差异。α-香附酮已被证明为镇痛和抗子宫痉挛的活性化合物,其机制研究较为深入。目前,治疗痛经的药物机制研究主要是针对可生成前列腺素的花生四烯酸代谢途径,然而,药物对疼痛信号传导的影响研究较少。传统中医药治疗原发性痛经具有良好的效果和较小的副作用,而香附与艾叶常配伍用于治疗原发性痛经,具有相当的研究价值,有待学者进一步的深入研究。
Forty-five literatures issued from the years of 1977 to 2016 referring to ＂the pathogenesis of primary dysmenorrhea and the therapeutic mechanism of Rhizoma Cyperi（Xiangfu）and Folium Artemisiae Argyi（Aiye）for dysmenorrhea＂were retrieved,summarized and analyzed through reviewing the databases of CNKI,Wanfang,and Web of Science with＂ Rhizoma Cyperi, Cyperus rotundus L., Folium Artemisiae Argyi, Artemisia argyi Lévl. et Vant.,uterus,primary dysmenorrhea,analgesic effects＂as the key words. The results showed that the pathogenesis of primary dysmenorrhea was closely associated with the expression of the biological factors of prostaglandins（PGs）,beta endophin（β-EP）,5-hydroxytryptamine（5-HT）,vasopressin,Ca^（2＋）,and nitric oxide（NO）. Various fractions of Xiangfu and Aiye had been proved to have varying degrees of analgesic activity. Alpha-cyperone had been confirmed as an active compound with analgesic and anti-hysterotrismus effects,and its mechanism had been well studied. Current studies on therapeutic mechanism of medicine for treating primary dysmenorrhea were more focused on the metabolic pathway of arachidonic acid generating prostaglandins rather than on the influence of pain signal transduction.Traditional Chinese medicine is effective and safe for the treatment of primary dysmenorrhea,and the herb-pair of Xiangfu and Aiye was frequently used during the treatment. Therefore,the therapeutic mechanism studies of Xiangfu and Aiye possess considerable research value and are worth of further research.
作者
范恺磊
蔡皓
刘晓
段煜
裴科
乔凤仙
汪小琦
徐洋洋
FAN Kailei CAI Hao LIU Xiao DUAN Yu PEI Ke QIAO Fengxian WANG Xiaoqi XU Yangyang(School of Pharmacy/Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023 Jiangsu, China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2017年第1期139-143,共5页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
江苏省高等学校大学生创新创业训练计划资助项目(201610315092X)
关键词
香附
艾叶
原发性痛经
作用机制
综述
Rhizoma Cyperi（Xiangfu）
Folium Artemisiae Argyi（Aiye）
primary dysmenorrhea
mechanism
review
