摘要
目的研究射频消融联合化学治疗在乳腺癌肝转移中临床效果。方法选择2009年1月~2011年3月在笔者医院进行治疗的乳腺癌肝转移患者89例,采用随机数字表分为观察组(n=44)和对照组(n=45),观察组采用射频消融术联合化疗进行治疗,对照组采用常规手术联合术后化疗进行治疗。对两组患者围手术期一般情况及术后生存情况进行分析。结果对照组患者手术耗时及术后住院时间均显著长于观察组(P<0.05);对照组患者术中出血率高于对照组,差异无统计学意义(χ2=1.870,P>0.05);对照组患者并发症发生率显著高于观察组(χ2=7.011,P<0.05)。术后1年内,对照组患者在生理功能,生理职能,情感职能,躯体疼痛和活力等方面评分均显著低于观察组(P<0.05);观察组在第1年,第3年和第5年的生存率分别为97.72%(43/44)、54.54%(24/44)和20.45%(9/44)。对照组在第1年,第3年和第5年的生存率分别为77.78%(35/45)、44.4%(20/45)和0。结论射频消融联合化学治疗乳腺癌肝转移能够提高患者生存率,且具有手术时间短、术后并发症发生率低、术后住院时间短的优势。
Objective To study tbe clinical effect of radiofrequency ablation combined with chemotherapy on liver metastasis of breast cancer. Methods Ejght nine patients with liver metastasis of breast cancer cured in our hospital from January 2009 to March 2011 were divided into observation group （ n = 44） and control group （ n = 45 ） according to the random number table. In the observation group, patients were treated with radiofrequency ablation combined with chemotherapy, while in the control group, patients were treated with con- ventional surgery combined with chemotherapy. The general condition in the perioperative period and survival condition of the two groups were analyzed. Results Operation time and postoperative hospitalization time in control group were significantly longer than that in the observation group （ P 〈 0.05 ）. The rate of blood loss in control group was higher than that in the control group, and the difference was not statistically significant （X2 = 1. 870, P 〉 0.05）. The incidence of complications in control group was significantly higher than that in ob- servation group （X2 = 7. 011, P 〈 0.05 ）. The score of physiological function, physiological function, emotional function, physical pain and vitality in control group were significantly lower than that in observation group （ P 〈 0.05 ）. The survival rate in observation group in first years, third years and fifth years were 97.72% （43/44）, 54.54% （24/44）, 20.45% （9/44）, respectively. While the survival rate in control group was 77.78% （35/45） ,44.4% （20/45） and 0% , respectively. Conclusion Radiofrequency ablation combined with chemotherapy can improve the survival rate of patients with liver metastasis of breast cancer, reduce operation time and postoperative hospitalization time, and decline incidence of postoperative complications.
出处
《医学研究杂志》
2017年第1期59-62,共4页
Journal of Medical Research
基金
河北省科技支撑计划项目(1213114ZD)
关键词
射频消融
化学治疗
乳腺癌肝转移
临床效果
Radiofrequency ablation
Chemotherapy
Breast cancer liver metastasis
Clinical effect
