摘要
目的:探讨对维持性血液透析继发性甲状旁腺功能亢进患者采用碳酸镧结合骨化三醇治疗的临床疗效。方法:36例维持性血液透析继发甲状旁腺功能亢进患者随机分为对照组和治疗组,对照组予以骨化三醇0.5μg/d,治疗组予以骨化三醇0.5μg/d+碳酸镧500mg 3次/d;观察治疗前及治疗后3个月的血钙、血磷及血甲状旁腺激素(iPTH)水平变化。结果:对照组治疗后3个月血钙、血磷、血iPTH与治疗前比较差异无统计学意义(P>0.05)。治疗组的血磷、血iPTH于治疗后3个月有显著改善(P<0.05),与对照组相比明显降低,差异有统计学意义(P<0.05)。结论:碳酸镧结合骨化三醇治疗可显著降低维持性血液透析患者血磷、血iPTH水平,从而有效缓解维持性血液透析患者的继发性甲状旁腺功能亢进。
Objective：To observe the effect of lanthanum carbonate combined with calcitriol in the treatment of hemodialysis patients with secondary hyperparathyroidism.Methods：Thirty-six patients undergoing maintenance hemodialysis were randomly divided into treatment group and control group.The control group were given calcitriol capsule（0.5μg/d）,treatment group were given lanthanum carbonate（500mg,3times a day）combined with caleitriol capsule.In 3months of treatment,serum calcium（Ca2＋）,serum phosphate（P3＋）and serum intact parathyroid hormone（iPTH）was observed respectively.Results：After 3months of treatment in control group,there was no statistical difference in the change of serum Ca2＋,serum P3＋and iPTH（P〉0.05）.In treatment group,serum P3＋and iPTH showed significant change after 3months of treatment（P〈0.05）.There was statistical difference on the serum P3＋and iPTH between treatment group and control group after 3 months respectively（P〈0.05）.Conclusion：Calcitriol combined lanthanum carbonate can obviously decreases the levels of serum P3＋,intact parathyroid hormone in hemodialysis patients,and relieve secondary hyperparathyroidism effectively.
出处
《医学理论与实践》
2017年第2期170-171,共2页
The Journal of Medical Theory and Practice
