摘要
目的系统研究天山假狼毒Stelleropsis tianschanica的化学成分。方法采用柱色谱技术对天山假狼毒的甲醇提取物进行分离纯化,用波谱技术结合化学方法进行结构鉴定。结果从天山假狼毒甲醇提取物中分离得到了12个化合物,包括5个木脂素类,3个二苯基戊醇衍生物,分别鉴定为kusunokinin(1)、pluviatolide(2)、邻苯二甲酸二丁酯(3)、邻苯二甲酸二丙酯(4)、对二苯酚(5)、瑞香酮(6)、2(S)-hydroxy-1-(4-hydroxy phenyl)-5-phcnyl-1-pentanone(7)、(2R,3R)-1,5-diphenylpentane-2,3-diol(8)、落叶松树脂醇(9)、异落叶松树脂醇(10)、马台树脂醇(11)、4α,5βH-guai-9,7(11)-dien-12,8-olide-12,8α-diol(12)。结论化合物1~12均为首次从该属植物中分离得到。
Objective To further study the chemical constituents of Stellerops＆ tianschanica. Methods The constituents were isolated and purified by silica gel chromatography repeatedly, and the structures were identified by spectra analysis and chemical methods. Results Twelve compounds including five lignans and three diphenylpentane derivatives were obtained, and named as kusunokinin （1）, pluviatolide （2）, dibutyl phthalate （3）, dipropyl phtalate （4）, p-dihydroxybenzene （5）, daphneolon （6）, 2（S）- hydroxy-l-（4-hydroxy phenyl）-5-phenyl-l-pentanone （7）, （2R,3R）-l,5-diphenylpentane-2,3-diol （8）. lariciresinol （9）, isolariciresinol （10）, matairesinol （11）, and 4α,5βH-guai-9,7（11）-dien-12,8-olide-12,8α-diol （12）. Conclusion Compounds 1--12 are all obtained from the plant ofS. tianschanica and the genus Stelleropsis Pobed. for the first time.
作者
石磊岭
赵丹
马国需
杨峻山
古丽娜.沙比尔
张晶
SHI Lei-ling ZHAO-Dan MA Guo-xu YANG Jun-shan GULINAR Sabir ZHANG Jing(Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi 830002, China College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China)
出处
《中草药》
CAS
CSCD
北大核心
2017年第1期58-61,共4页
Chinese Traditional and Herbal Drugs
基金
新疆维吾尔自治区卫生计生委青年科技人才专项(2015Y39)
新疆维吾尔自治区公益性科研院所基本科研业务(KY2015129)
新疆维吾尔自治区自然科学基金面上项目(2013211A111)
