摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与ApoB/ApoAⅠ的相关性。方法收集单纯鼾症患者29例,OSAHS患者50例的基本信息及甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、LDL-C/HDL-C、ApoAⅠ、ApoB、ApoB/ApoAⅠ、血糖(Glu)、血尿酸(UA)、睡眠监测结果。结果 OSAHS组血ApoB/ApoAⅠ、BMI较对照组明显增加(P<0.05),两组TG、TC、HDL-C、LDL-C、LDL-C/HDL-C、ApoAⅠ、ApoB、Glu、UA、年龄、性别、口服降脂药情况差异均无统计学意义(P>0.05)。并且,ApoB、ApoB/ApoAⅠ、BMI与呼吸暂停低通气指数(AHI)呈正相关(r=0.243、0.298、0.281,P<0.05)。结论肥胖是OSAHS的重要危险因素,并且BMI与AHI呈正相关。OSAHS患者与单纯鼾症患者相比血ApoB/ApoAⅠ明显升高,并且血ApoB、ApoB/ApoAⅠ与OSAHS严重程度正相关。
Objective To investigate the relationship between obstructive sleep apnea hypopnea syndrome（OSAHS）and ApoB/ApoAⅠ.Methods Twenty-nine patients with only snoring and 50 patients with OSAHS were enrolled.The baseline data,laboratorial index（TG,TC,HDL-C,LDL-C,LDL-C/HDL-C,ApoAⅠ,ApoB,ApoB/ApoAⅠ,Glu,UA）and sleep monitoring results（AHI）of all patients were collected.Results Compared with the control group,ApoB/ApoAⅠ and BMI were significantly increased in OSAHS group（P〈0.05）.TG,TC,LDL-C,HDL-C,LDL-C/HDL-C,ApoAⅠ,ApoB,Glu,UA,age,gender and oral lipid-lowering drug showed no significant difference between two groups（P〉0.05）.Moreover,ApoB,ApoB/ApoAⅠ,BMI showed linear correlation with AHI respectively（r =0.243,r =0.298,r =0.281,respectively,P〈0.05）.Conclusion Obesity was a major risk factor of OSAHS,BMI and AHI were positively correlated.Compared with the control group the apoB/ApoAⅠincreased significantly in OSAHS group,apoB and apoB/ApoAⅠ and the severity of OSAHS were positively correlated.
出处
《临床荟萃》
CAS
2017年第1期64-67,共4页
Clinical Focus
