摘要
目的 分析土三七水煎剂对老年多发骨折术后并发高血压患者血液流变学的影响。 方法 选取湖北医药学院附属人民医院2014年5月至2015年12月收治的80例老年多 发骨折术后并发高血压患者作为研究对象。完全随机分为对照组及观察组，各40例。对照组采用硝苯地平控释片30 mg/次、1次/d口服，观察组采用中药土三七水煎剂300 ml每日分 早晚2次服用，比较2组患者治疗总有效率、用药不良反应发生率、血液流变学指标。 结果 观察组患者治疗总有效率高于对照组、用药不良反应发生率低于对照组，差异有统 计学意义［90.0%（36/40）比75.0%（30/40）、5.0%（2/40）比20.0%（8/40）］（P＜0.05）。观察组全血黏度（高切、低切）、全血还原指数、血浆黏度、红细胞聚集指数、血 细胞比容低于对照组，红细胞沉降率高于对照组，差异有统计学意义［（4.2±0.8）mPa·s比（4.9±0.9）mPa·s、（13.0±2.9）mPa·s比（15.8±3.0）mPa·s、（9.4±1.8） 比（12.0±1.9）、（1.4±0.3）mPa·s比（1.6±0.3）mPa·s、（8.0±1.2）比（9.6±1.2）、（43.3±2.0）%比（45.6±2.1）%、（10.2±1.2）mm/1 h比（8.8±1.2）mm/1 h ］（P〈0.05）。 结论 土三七水煎剂治疗老年多发骨折术后并发高血压效果理想，血液流变学平稳。
Objective To analyze the clinical effect of Gynura segetum water decoction on hemorheological variation in elderly patients with postoperative hypertension after multiple fracture operation. Methods Totally 80 elderly patients with postoperative hypertension after multiple fracture operation from May 2014 to December 2015 in Renmin Hospital, Hubei University of Medicine were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with nifedipine controlled-released tablets and the observation group was treated with Gynura segetum water decoction. Total effective rate, incidence of adverse reactions and hemorheological indexes were analyzed. Results In observation group, total effective rate was significantly higher than that in control group, adverse reaction incidence was significantly lower than that in control group[90.0%（36/40） vs 75.0%（30/40）, 5.0%（2/40） vs 20.0%（8/40）]（P〈0.05）. In observation group, whole blood viscosity（high shear rate, low shear rate）, whole blood reduction index, plasma viscosity, erythrocyte aggregation index and red blood cell hematocrit were significantly lower than those in control group; erythrocyte sedimentation rate was significantly higher than that in control group[（4.2±0.8）mPa·s vs （4.9±0.9）mPa·s, （13.0±2.9）mPa·s vs （15.8± 3.0）mPa·s, （9.4±1.8） vs （12.0±1.9）, （1.4±0.3）mPa·s vs （1.6±0.3）mPa·s, （8.0±1.2） vs （9.6±1.2）, （43.3±2.0）% vs （45.6±2.1）%, （10.2 ±1.2）mm/1 h vs （8.8±1.2）mm/1 h]（P〈0.05）. Conclusion Gynura segetum water decoction treating postoperative hypertension in elderly patients after multiple fracture operation is effective and the hemorheological variation is stable.
出处
《中国医药》
2017年第1期110-113,共4页
China Medicine
基金
湖北省教育厅科学技术研究项目（B20112115）
关键词
多发骨折
血液流变学
土三七水煎剂
高血压
Multiple fractures
Hemorheology
Gynura segetum water decoction
Hypertension
