摘要
目的观察贝那普利联合螺内酯治疗心力衰竭患者的疗效及对肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的影响。方法选取2014年11月—2015年10月青海省心脑血管病专科医院心律失常一科诊治的心力衰竭患者66例作为研究对象,根据随机数字表法分为2组,每组33例。对照组为常规药物加贝那普利治疗,观察组在此基础上加螺内酯治疗。比较2组患者的治疗效果;治疗前和治疗5个月后的左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、5分钟步行距离;TNF-α、IL-6水平变化;记录不良反应。结果治疗后,观察组的临床疗效显著高于对照组(87.88%vs.60.61%,x^2=6.418,P=0.011)。与治疗前比较,2组治疗后TNF-α、IL-6、LVESD、LVEDD均下降,LVEF、5 min步行距离均提高(P<0.05);且治疗后观察组TNF-α、IL-6水平显著低于对照组[(6.57±0.61)ng/L vs.(7.86±0.76)ng/L,(29.43±2.45)ng/L vs.(38.65±3.54)ng/L,t=7.604、12.303,P<0.05];LVESD、LVEDD显著低于对照组[(43.54±3.08)mm vs.(47.05±3.25)mmn,(51.24±4.57)mm vs.(56.54±5.02)mm,t=4.503,4.485,P<0.05],LVEF、5 min步行距离显著高于对照组[(45.54±4.87)%vs.(38.54±4.05)%,(282.54±25.42)m vs.(252.32 4-22.54)m,t=6.349、5.110,P<0.05]。结论贝那普利联合螺内酯能有效降低心力衰竭患者TNF-α、IL-6、LVESD、LVEDD水平,升高LVEF水平,安全性高。
Objective To observe the curative effect of lotensin combined with spironolactone in the treatment of pa -tients with heart failure and effect on tumor necrosis factor alpha （ TNF-α） and interleukin 6 （ IL-6） .Methods From Novem-ber 2014 to October 2015 , selecting 66cases of patients with heart failure in Qinghai cardiovascular and cerebrovascular dis -ease hospital ,department of arrhythmia , according to the method of random numbers , all the patients were divided into obser-vation group and control group , 33 cases in each group .Control group were treated with conventional drugs with Benazepril for treatment, observation group on the basis of control group were given spironolactone for treatment .Compared the two groups before and after five months of treatment with left ventricular end systolic diameter （ LVESD） , left ventricular end diastolic di-ameter （ LVEDD） , left ventricular ejection fraction （ LVEF） , 5 minutes walking distance , tumor necrosis factor alpha （ TNF-α）, interleukin 6 （IL-6） level changes, and adverse reaction.Results After treatment, the clinical curative effect of obser-vation group was significantly higher than the control group （87.88%vs.60.61%,χ2 =6.418, P =0.011）.Compared with before treatment, after treatment of the 2 groups of TNF-α, IL-6, LVESD, alpha 6 LVEDD decreased, LVEF, 5 min walking distance were increased （ P 〈0.05）; and after treatment the observation group TNF-α, IL-6 level was significantly lower than the control group[（6.57 ±0.61） ng/L vs.（7.86 ±0.76） ng/L,（29.43 ±2.45） ng/L vs.（38.65 ±3.54） ng/L, t =7.604, t =12.303;P 〈0.05].LVESD and LVEDD were significantly lower than the control group [（43.54 ±3.08）mm vs.（47.05 ±3.25） mm, （51.24 ±4.57） mm vs.（56.54 ±5.02） mm, t =4.503, t =4.485, P 〈0.05], LVEF and 5 min walking distance was significantly higher than that of control group [（45.54 ±4.87）% vs.（38.54 ±4.05）% and （282.54 ±25.42） m vs.（252.32 ±22.54） m, t =6.349,
出处
《疑难病杂志》
CAS
2017年第1期14-17,共4页
Chinese Journal of Difficult and Complicated Cases
