摘要
目的:观察自拟消毒汤与中药保留灌肠联用对肛瘘患者术后分泌型免疫球蛋白A(SIg A)、表皮生长因子(EGF)及创面恢复的影响。方法:选取2014年1月至2015年1月我院肛肠科行肛瘘手术的116例患者,随机将患者分至对照组(n=60例)及观察组(n=56例),2组患者术后均予以痔宁片、左氧氟沙星等常规基础治疗,对照组患者在常规治疗基础上予以高锰酸钾液熏洗,并进行常规换药;观察组患者在常规治疗基础上予以自拟消毒汤内服及自拟中药保留灌肠联用治疗,分别在术后2天及术后14天检测2组患者的SIg A、EGF水平,比较2组患者的创面恢复情况(包括创面渗液情况、腐肉脱落时间、肛周瘙痒情况、创面愈合时间、创面缩小率、新生上皮出现时间等)。结果:术后第1天,2组患者的创面渗液、肛周瘙痒、肛周水肿积分比较差异无统计学意义(P>0.05);术后14天,2组患者的创面渗液、肛周瘙痒、肛周水肿积分均明显低于术后第1天;且观察组积分明显低于对照组(均P<0.05)。观察组患者的腐肉脱落时间、创面愈合时间、新生上皮出现时间均明显短于对照组(P<0.05)。术后第1天,2组患者的SIg A、EGF水平比较差异无统计学意义(P>0.05);术后14天,2组患者的SIg A、EGF水平均明显高于治疗前,且观察组明显高于对照组(P<0.05)。观察组患者的有效率为96.43%,明显高于对照组的83.33%(P<0.05)。结论:在肛瘘术后患者予以自拟消毒汤与中药保留灌肠联用治疗,能有效提升患者的SIg A、EGF水平,减轻创面的疼痛,促进创面的愈合。
Objective： To investigate the influence of Self-made Xiaodu Decoction combined with retention enema on SIg A,EGF and its influence on wounds healing after anal fistula operation. Methods： 116 patients in our hospital anorectal line anal fistula surgery collected from January 2014 to January 2015,randomized dievided into controlled group（ n = 60patients） and observation group（ n = 56patients）,2groups patients both accepted Zhi＇ ning Tablets,levofloxacin and other conventional basic therapy after surgery,the controlled group of patients accepted potassium permanganate solution fumigation on the basis of the conventional therapy,and regular dressing; the observation group was given Self-made Xiaodu Decoction combined with retention enema,after 2days and 14 days,detected SIg A and EGF levels and were compared between the two groups of patients with wound healing（ including wound exudate,slough off time,perianal itching,the wound healing time,reduced the rate of wound newborn epithelium time,etc.）. Results： The 1stday after operation,2groups of patients with wound exudate,perianal itching,perianal edema points difference was not statistically significant（ P〈0. 05）; the 14 thday after operation,2groups of patients with wound exudate,perianal itching,points perianal edema were significantly lower than the 1stday after operation; integral of the observation group was significantly lower than the controlled group（ all P〈0. 05）. Carrion off time,wound healing time,new epithelium time of theobservation group were shorter than the controlled group（ P〈0. 05）. The 1stday after operation,SIgA,EGF level of the 2groups was not statistically significant（ P〉0. 05）; the 14 thday after operation,SIgA,EGF levels of the 2groups were significantly higher than before treatment,the observation group was significantly higher than the controlled group（ P〈0. 05）. The effective rate of the observation group were 96. 43%,significantly higher than the controlled groups which was 83. 33%（ P〈0
出处
《四川中医》
2017年第1期132-135,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
保留灌肠
消毒汤
创面愈合
Retention enema
Xiaodu Decoction
Wounds healing
