摘要
目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者发生静脉栓塞的危险因素,为其临床诊治和预后提供支持。方法回顾性分析2013年1月—2015年12月杭州市第三人民医院收治的239例AECOPD患者病例。按照患者预后是否出现静脉血栓栓塞(VTE)情况进行分组,其中发生VTE组患者52例,无VTE组患者187例。制作危险因素分析调查表,收集患者年龄、吸烟史、BMI、肺功能分级、卧床时间、合并高血压或冠心病等因素情况,并统计2组常见血清指标及血气指标水平,并采用单因素和Logistic回归分析对收集的2组间数据资料进行分析。结果 239例AECOPD患者中52例发生VTE,VTE发生率达到了21.8%。单因素和Logistic回归分析结果显示,年龄、BMI、吸烟史、肺功能分级、糖尿病、合并高血压或冠心病、卧床时间、高D-二聚体水平、Pa O_2、Pa CO_2是AECOPD患者并发VTE的危险因素。结论 AECOPD患者临床易出现VTE并发症,而患者年龄、BMI、吸烟史、肺功能分级、糖尿病、合并高血压或冠心病、卧床时间、高D-二聚体、Pa O_2、Pa CO_2水平是AECOPD患者发生VTE的危险因素。
Objective To investigate the risk factors of acute exacerbation chronic obstructive pulmonary disease（AECO- PD） with venous thromboembolism, and to provide support for clinical diagnosis and prognosis. Methods All 239 cases of AECOPD patients from January,2013 to December,2015 in our hospital were retrospectively analyzed. Based on with or without venous thromboembolism（ VTE）, patients were divided into two groups,52 cases in VTE group and 187 cases in without VTE group. Survey on risk factors of AECOPD with VTE were made, and age, smoking history, body mass index, severity, time in bed, diabetes, hypertension or coronary heart disease of patients were selected, and the common serum in- dicators and blood gas levels were observed. Univariate factor and Logistic Regression analysis were carried out to analysis the data between two groups. Results In all 239 cases of AECOPD patients,52 cases were with VTE, the VTE incidence rate reached 21.8%. Univariate and Logistic regression analysis showed that age, body mass index, smoking history, diabe- tes, hypertension or coronary heart disease, bed time, high D-dimer level, PaO2 level, PaCO2 level are the risk factors for AECOPD patients with VTE. Conclusion COPD patients easily occur VTE complications, and age, body mass index, smoking history, diabetes, hypertension or coronary heart disease, bed time, high D-dimer level, PaO2 level, PaCO2 level are risk factors of AECOPD with VTE.
作者
董洪英
张云霞
DONG Hong-ying ZHANG Yun-xia.(Department of Respiratory Medicine, the 3th hospital of Hangzhou , Hangzhou , Zhejiang 310000, China)
出处
《中华全科医学》
2017年第1期76-78,共3页
Chinese Journal of General Practice
关键词
慢性阻塞性肺疾病
急性加重期
合并静脉血栓
危险因素
Chronic obstructive pulmonary disease
Acute exacerbation
The inferior vena cava thrombosis
Risk Factors
