摘要
microRNA-221(miRNA-221)为小的非编码调控基因,作为致瘤性miRNA,转录后负向调控靶基因的表达在人类多种恶性肿瘤中表达上调,参与肿瘤的发生发展,是目前被普遍认可的作用机制。miRNA-221在恶性肿瘤中的表达及意义也已成为当前肿瘤研究热点之一。目前研究表明miRNA-221可促进肿瘤上皮间质转化,增强肿瘤细胞的转移和侵袭能力。miRNA-221在宫颈癌及卵巢癌中的表达具有重要意义,为临床诊断或治疗提供新思路。
microRNA-221 （ miRNA-221） are small noncoding gene that function as an oncogene, people found that miRNA-221 are overexpression in variety of malignant carcinoma and this is associated with the occurrence of tumor. The mechanism of action that negative target genes regulators at the post-transcriptional level is now widely recognized. The expression and significance of miRNA-221 in malignant tumor has become one of hot topic in current cancer research. The present study showed that miRNA-221 an promote tumor EMT and enhance metastasis and invasion ability of tumor cells. In cervical cancer and ovarian cancer, the expression of miRNA-221 has great significance of providing new ideas for clinical diagnosis or treatment.
出处
《妇产与遗传（电子版）》
2016年第1期51-55,共5页
Obstetrics-Gynecology and Genetics (Electronic Edition)
