摘要
目的制备用于抗氧化保健作用的新型透颊膜给药制剂。方法采用成膜材料壳聚糖,制备中药橙皮苷壳聚糖膜剂;以膜剂的外观质量、抗拉力强度、溶解时间、黏附时间、体外黏附力及药物释放度作为评价指标,优选最佳制备方法,并采用紫外分光光度法测定橙皮苷的含量。结果所制膜剂易成膜、起膜,透明度高,均匀性良好,测定波长为420 nm。结论该膜剂处方合理,引起的生物组织反应小,可为口腔科常见疾病防治提供新的剂型。
Objective To prepare novel buccal film formulation anti oxidation and health care function. Methods The chitosan film was prepared by ehitosan as the film- forming material. The appearance quality,tensile strength,dissolution time,adhesion time,in vitro adhe- sion and drug release were used as evaluation indexes. The content of hesperidin was determined by ultraviolet speetrophotometry. Results The films were easy to form and film, and the transparency was high and the homogeneity was good. The measurement wave- length was 420 nm. Conclusion The formulation of this film is reasonable, and the biological tissue reaction is small. It can provide a new dosage form for the prevention and treatment of common diseases in the Department of Stomatology.
出处
《中国药业》
CAS
2017年第1期19-22,共4页
China Pharmaceuticals
关键词
橙皮苷
壳聚糖
膜剂
制备工艺
hesperidin
chitosan polymers
membrane
preparation techonlogy
