摘要
细菌和病毒在慢性阻塞性肺疾病(COPD)急性加重和疾病进展中起着举足轻重的作用,稳定期COPD患者气道内细菌和病毒负荷与气道炎症直接相关,能起到维持炎症状态的作用。该综述对不同临床条件下相关宿主肺微生物动力学及其与免疫反应的相互作用进行了回顾分析,对细菌-病毒负荷在慢性阻塞性肺疾病中的研究进展作一综述。
Bacteria and viruses play a critically important role in acute exacerbation and progression of chronic obstructive pulmonary disease （COPD）, the bacterial and viral loads in airways of patients with stable COPD are directly associated with airway inflammations and play a role of maintaining the inflammatory state. The host lung microbial dynamics under different clinical conditions and its interaction with the body＇s immune response were retrospectively analyzed in the review, and the progress of research on role of bacterial-viral load in COPD is reviewed.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第2期473-476,共4页
Chinese Journal of Nosocomiology
基金
安徽省科技攻关计划资助项目(1604a0802091)
国家自然科学基金资助项目(81571528)
关键词
慢性阻塞性肺疾病
细菌感染
病毒感染
定植
Chronic obstructive pulmonary disease
Bacterial infection
Viral infection
Colonization
