摘要
以邻溴苯甲醛和取代端基炔类化合物为原料，叔丁胺为氮源，DMAc为溶剂，CuI作用下，通过微波辐射多组分一锅法简洁、高效地合成了一系列3-取代异喹啉类衍生物，产率在66%-98%之间.此方法为3-芳基异喹啉衍生物的合成提供了一种高效、快速的合成方法.
In this paper, a CuI mediated one-pot muti-component method for the preparation of isoquinoline derivatives under microwave irradiation was developed by using 2-bromobenzaldehyde and terminal alkynes as starting materials, tert-butyl amine as nitrogen source. This methodology provides one convenient and high efficient approach to the 3-substituted isoquinoline library.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2016年第12期2906-2911,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21272091)
华中师范大学中央高校基本科研业务费(No.CCNU15A02014)资助项目~~
关键词
3-芳基异喹啉衍生物
碘化亚铜
微波辐射
多组分反应
3-substituted isoquinolines
copper iodide
microwave irradiation
multiple component reaction
