摘要
目的:应用扩散峰度成像(DKI)研究慢性高原病(CMS)患者与正常人大脑灰白质微结构的差异。方法:收集21例CMS患者为病例组,20例健康志愿者为正常对照组,均行常规头颅MR及DKI序列扫描,分别测量两组大脑灰白质各感兴趣区(ROI)内的平均峰度(MK)值、径向峰度(RK)值及峰度各向异性(KA)值,分别统计各组同一部位左右两侧ROI参数,符合正态分布,采用配对样本t检验;统计两组间同侧同一部位ROI参数,符合正态分布,采用两独立样本t检验。结果:同组比较,CMS组两侧内囊前肢KA值及两侧尾状核头、丘脑MK值、RK值存在侧别差;对照组两侧内囊前肢MK值、KA值及丘脑MK值、RK值存在侧别差;两组的右侧内囊前肢的KA值较对侧减低,右侧丘脑MK及RK值较对侧增高。两组间对比,胼胝体膝部RK值有显著性,CMS组低于对照组;胼胝体压部KA值、左侧内囊前肢MK值、左侧内囊后肢RK值、右侧尾状核头MK值、双侧豆状核MK值及右侧丘脑MK值、KA值差异有显著性,CMS组高于对照组。结论:高海拔地区正常人及CMS患者左右大脑半球微结构并非完全对称,部分脑区存在差异。CMS患者脑组织对高原低氧环境敏感性及反应性不一,胼胝体、基底节区及丘脑与正常组均有不同程度差异性。
Objective To explore the differences between patients withehronic mountain sickness （CMS） and healthy people in the mierostructure of brain gray and white matter by using diffusion kurtosis imaging （DKI）. Methods 21 CMS patients were recruited to a study group and 20 healthy volunteers were assigned to a control group. Both groups received conventional MRI and DKI sequence scans. The mean kurtosis （MK） values, radial kurtosis （RK） values and kurtosis anisotropy （KA） values in each region of interest （ROI） in the cerebral gray and white matter were measured and the same part of the left and right side ROI parameters was counted. The data satisfied the normal distribution and the paired samples t-test was used; the ROI parameters between the two groups in the same parts of the same side followed the normal distribution and the two independent samples t-test was used. Results The KA values in both sides of the anterior limb of internal capsule, the MK values and RK values in bilateral caudate nucleus head and thalamus had side difference in CMS group. In both sides of the anterior limb of the internal capsule＇s MK values, KA values and thalamus＇s MK values, RK values existed side difference in the control group. The KA values of the right anterior limb in internal capsule were lower than those in the left in both groups; the right thalamus＇s MK values and RK values were higher than the other side. The RK value in genu of corpus callosum differed significantly, and it was lower the CMS group than in the control group. The difference of the KA values in corpus eallosum, the MK value in the left anterior limb of internal capsule, the RK values in the left posterior limb of internal capsule, the MK values in the right caudate nucleus head, the MK values in bilateral lentieular nucleus and the MK values and KA values in the right thalamus were significant, and they were higher inthe CMS group than in the control group. Conclusions The left and right cerebral hemispheric micro- structure is n
出处
《实用医学杂志》
CAS
北大核心
2017年第1期127-130,共4页
The Journal of Practical Medicine
基金
青海省科学技术厅资助项目(编号:2015-ZJ-749)
关键词
慢性高原病
大脑微结构
磁共振成像
扩散峰度成像
Chronic mountain sickness
Brain micro structure
Magnetic resonance imaging
Diffusion kurtosis imaging
