摘要
目的探讨血小板活化因子(PAF)与C反应蛋白(CRP)监测在原发性高血压患者心脑血管内皮损伤及病情进展中的作用。方法收集我院2015年1月~2016年1月收治的58例原发性高血压患者为实验组,收集50例健康体检者作为对照组,检测两组患者的PAF和CRP水平。结果实验组与对照组的PAF水平分别为(155.80±35.81)、(80.94±20.77)ng/ml,CRP水平分别为(9.87±3.57)、(2.11±0.94)mg/L,两组的PAF、CRP水平差异有统计学意义(P<0.05);不同性别患者的PAF、CRP水平差异无统计学意义(P>0.05),年龄≥50岁患者的PAF、CRP水平均高于年龄<50岁的患者(P<0.05),随着患者病程的增加,PAF水平显著增高(P<0.05),而CRP水平增高不显著(P>0.05);PAF与患者年龄成正相关,同时与CRP成正相关,PAF、CRP与PAR、WBC、PLT、FIB、CHOL、收缩压成正相关。结论 PAF、CRP水平对监测原发性高血压患者心脑血管内皮损伤及病情变化具有较高价值,值得推广。
Objective To explore the role of platelet activating factor（PAF） and C reactive protein（CRP）level in cardio-cerebral-vascular endothelial injury and its disease development in patients with primary hypertension.Methods From January 2015 to January 2016,58 patients with primary hypertension were collected in our hospital were the experimental group,while 50 healthy participants from physical examinationwere collected and classified into the control group.The indexes of PAF and CRP in the two groups were tested.Results The PAF levelin the experimental group and the control group was（155.80±35.81） ng/ml and（80.94±20.77） ng/ml respectively,and the CRP level was（9.87±3.57） mg/L and（2.11±0.94） mg/L,and there was a statistical difference of PAF and CRP level（P〈0.05）.The PAF and CRPlevel in gender were not displayed obvious difference（P〉0.05）.PAF and CRP level in patients aged over 50 years old were both higher than those in patients less than 50 years old（P〈0.05）.Along with the increase of the course of diseasein patients,PAF levelwas greatly increased（P〈0.05）,while CRP level was not in obvious increase（P〉0.05）.PAF had a positive correlation with age,as well as CRP.PAF and CRP had positive correlations with PAR,WBC,PLT,FIB,CHOL and SBP.Conclusion PAF and CRP level have a higher value on monitoring cardio-cerebral-vascular endothelial injuryand disease changein patientswith primary hypertension,which is suitable for promotion.
出处
《中国当代医药》
2017年第1期68-70,共3页
China Modern Medicine
关键词
C反应蛋白
血小板活化因子
原发性高血压
C-reactive protein
Platelet-activating factor
Primary hypertension
