摘要
目的 ：探讨胆管癌术后患者CXCL12的表达水平与疾病预后的关系,为临床判断胆管癌术后恢复情况提供客观依据。方法：选取2007年2月—2010年7月105例符合纳入标准的胆管癌术后患者作为研究对象。对105例患者术后CXCL12的表达水平进行测定,按表达水平分为低表达组（CXCL12〈5000 pg/m L）、中表达组（CXCL12 5000-6000 pg/m L）和高表达组（CXCL12〉6000 pg/m L）,比较3组临床病理参数,并采用门诊随访与电话随访相结合,按时记录3组患者临床资料及存活率和肿瘤复发情况。采用单因素及多因素分析胆管癌术后复发的相关危险因素。结果：胆管癌手术后3组的CXCL12表达水平较手术前（P〈0.05）均有下降,差异有统计学意义（P〈0.05）,并且术后1个月时3组患者血清CXCL12表达水平差异仍有统计学意义（P〈0.05）。低表达组的术后1、3、5年生存率均明显高于中表达组和高表达组（P〈0.05）,而肿瘤复发率则明显低于中表达组和高表达组,差异均有统计学意义（P〈0.05）;中表达组术后1、3、5年生存率均高于高表达组（P〈0.05）,而肿瘤复发率则低于高表达组（P〈0.05）。单因素及多因素分析显示胆管癌的5年生存率与肿癌直径,有无血管侵犯、淋巴结转移,肿瘤分化程度和CXCL12表达水平有关（P〈0.05）。结论：通过检测患者术后血清CXCL12表达水平可对患者的生存期、复发率等预后情况进行评估。此外肿癌直径大小,有无血管侵犯、淋巴结转移和肿瘤分化程度等均为影响胆管癌切除术后5年生存率的独立危险因素,可协助为胆管癌术后的预后评估提供参考价值。
Objective： To investigate the relationship between the expression of CXCL12 and the prognosis of patients with bile duct carcinoma, and to provide objective evidence for the clinical judgment of postoperative recovery. Methods： 105 patients with biliary tract cancer who were admitted to the Department of hepatobiliary surgery in their hospital from July 2010 to February 2007 were randomly selected as the research object. Of 105 cases of patients after operation of CXCL12 expression levels were detected, according to the expression levels of CXCL12, the patients were divided into low expression group （CXCL12 〈 5000 pg/mL）, medium expression group （CXCL12 5000 pg/mL〈 CXCL12 〈 6000 pg/mL） and high expression group （CXCL12 〉 6000 pg/mL）. The clinical and pathological parameters among the three groups were compared, The patients were followed up by using outpatient follow-up method and telephone follow-up mehod. The clinical data, survival rate and recurrence of the tumor in three groups of patients were recorded. The risk factors associated with the recurrence of bile duct carcinoma were analyzed by single factor and multiple factor analysis. Results： The expression of CXCL12 in the three groups were significantly lower than those before surgery, and the difference was statistically significant （P〈0.05）, and after operation 1 month, there was still a big differences in the levels of serum CXCL12 among the three groups. The 1, 3, 5-year survival rates in low expression group were significantly higher than the median expression group and high expression group, while the tumor recurrence rates were significantly lower than the median expression group and high expression group, the differences were statistically significant（P〈0. 05）. 1,3, 5-year survival rates in median expression group were higher than the high expression group, while the tumor recurrence rates were lower than the high expression group （P〈0.05）. Single factor and multiple factors analysis showed that the diame
出处
《中国现代普通外科进展》
CAS
2016年第11期870-873,876,共5页
Chinese Journal of Current Advances in General Surgery
关键词
胆管肿瘤
CXCL12
复发
生存
预后
Bile duct neoplasms · CXCL12 · Recurrence· Survival· Prognosis
