摘要
目的探讨双水平气道正压通气配合氨溴索对老年慢阻肺急性加重期(AECOPD)合并呼吸衰竭患者免疫功能及肺功能的影响。方法选取行AECOPD合并呼吸衰竭治疗的老年患者68例,按照随机数字表法分为观察组和对照组各34例。对照组单纯采用双水平正压通气进行治疗,观察组在对照组治疗的基础上配合使用氨溴索,观察治疗后2组患者的疗效、免疫功能及肺功能。结果观察组总有效率为85.29%,显著高于对照组的64.71%(P<0.05);治疗后2组患者各项免疫功能指标均较治疗前有所改善,组内比较除对照组Ig A和Ig G差异无统计学意义外(P>0.05),其余均有统计学意义(P<0.05)。治疗后观察组各项指标改善优于对照组(P<0.05);治疗后2组患者肺功能各项指标均较治疗前有所提高,组内比较除观察组FEV1.0、FVC外(P>0.05),其余差异均有统计学意义(P<0.05);治疗后观察组各项指标改善幅度均优于对照组(P<0.05)。结论双水平气道正压通气配合氨溴索治疗老年AECOPD合并呼吸衰竭效果显著,能明显改善患者免疫功能和肺功能,可在临床广泛使用。
Objective To discuss the effectr of bi - level positive airway pressure ventilation combined with ambroxol on immune function and pulmonary function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） compli- cated with respiratory failure. Methods 68 cases of patients with AECOPD complicated with respiratory failure treated in our hospital were selected and divided into observation group and control group with 34 cases in each group according to the random digital table method. The control group were given single bi - level positive airway pressure ventilation, and the observation group were combined am- broxol based on the control group. The therapeutic effect,immune function and pulmonary function of the two groups were observed after treatment. Results The total effective rate of the observation group was 85.29%, significantly higher than that of 64.71% in the control group （P 〈 0.05）. After treatment,the indexes of immune function in the two groups were improved compared with the prior treatment, and there were significant differences in other indexes except for IgG and IgA in the control group（P 〈 O. 05 ）. After treatment, the inde- xes of the observation group were better than those of the control group （P 〈 0.05）. The indexes of lung function in the two groups were improved after treatment,and the there were significant differences in other indexes except for FEV1 and FVC in the observation group （P 〈 0. 05 ）. The improvement of the observation group were better than those of the control group after treatment （ P 〈 0. 05 ）. Conclusion The therapeutic effect of bi - level positive airway pressure ventilation combined with ambroxol in the treatment of elderly patients with AECOPD complicated with respiratory failure can significantly improve the patientg immune function and pulmonary func- tion and can be widely used in clinical.
出处
《宁夏医学杂志》
CAS
2016年第12期1162-1164,共3页
Ningxia Medical Journal
关键词
双水平气道正压通气
氨溴索
老年慢性阻塞性肺疾病
呼吸衰竭
Keywords Bi - level positive airway pressure ventilation
Ambroxol
Acute exacerbation of chronic obstructive pulmonarydisease
Respiratory failure
