摘要
目的对Sysmex CA-1500凝血仪D-二聚体进行性能评价,探讨D-二聚体在老年性腰椎退变性疾病患者术后诱发深静脉血栓(DVT)形成的临床诊断价值。方法参考CLSI EP5-A2方案对D-二聚体性能进行评价。收集临床诊断为老年腰椎退变性疾病患者37例,对患者术前及术后不同时间点血清中D-二聚体进行定量检测。结果 D-二聚体的准确度、不精密度、线性范围、携带污染率、临床可报告范围均符合厂家要求。在37例患者中术后即刻与术后2周D-二聚检测值较高,处于临床血栓高风险状态;围术期内不同时间D-二聚体检测与术前相比有明显差异,具有统计学意义(P<0.01)。结论老年性腰椎退变性疾病以D-二聚体作为术后下肢深静脉血栓形成的预测和诊断手段,其灵敏性、特异性以及准确性均相对较高。
Objective To evaluate the performance of D-dimer of Sysmex CA-1500 coagulometer,and to evaluate the clinical value of D-dimer in the diagnosis of deep vein thrombosis（ DVT） after lumbar degenerative disease. Methods The performance of D-dimer was evaluated by referring to CLSI EP5-A2. A total of 37 patients with senile degenerative lumbar degenerative diseases were collected,and serum D-dimer was quantitatively measured at different time points before and after operation. Results D-dimer accuracy,imprecision,linear range,carrying pollution,clinical reportable range were in line with manufacturers requirements. D-dimer detection was higher in 37 patients and at 2 weeks＇ post-operatively,which was at high risk of clinical thrombosis. D-dimer detection was significantly different at different time points before and after operation,with the differences statistically significant（ P 0. 01）. Conclusion D-dimer is the predictive and diagnostic method of deep venous thrombosis of the lower extremity after senile degenerative lumbar degeneration. The sensitivity,specificity and accuracy of the method are relatively high.
出处
《中国卫生检验杂志》
CAS
2016年第24期3558-3560,3563,共4页
Chinese Journal of Health Laboratory Technology
关键词
D-二聚体
性能评价
老年腰椎退变性疾病
D-dimer
Performance evaluation
Elderly lumbar degenerative disease
