摘要
目的研究C-反应蛋白(CRP)和D-二聚体(D-dimer)在高脂血症性急性胰腺炎(HLAP)及胆源性急性胰腺炎(BAP)患者中的变化。方法选择2012年1月至2014年12月该院住院急性胰腺炎患者155例,根据病因分为HLAP组和BAP组。根据严重程度分为轻度急性胰腺炎(MAP)亚组和中度急性胰腺炎(MSAP)亚组。检测血常规、肝肾功能、血糖(Glu)、血钙(Ca2+)、总胆红素(TBIL)和直接胆红素(DBIL)、CRP和D-dimer。结果HLAP组的血小板(PLT)、Glu和血脂指标胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及三酰甘油(TG)均明显高于BAP组,而丙氨酸转氨酶(ALT)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、TBIL、DBIL、Ca2+和血肌酐(Cr)则明显低于BAP组(P<0.05)。HLAP组的CRP明显高于BAP组并且差异有统计学意义(P<0.01)。MAP、MSAP亚组中的HLAP组与BAP组相比较,CRP差异均有统计学意义(P<0.01)。HLAP组MAP和MSAP亚组间的CRP和D-dimer差异均有统计学意义(P<0.01),BAP组MAP和MSAP亚组间的CRP和D-dimer差异也均有统计学意义(P<0.01)。HLAP组的CRP和D-dimer升高均是出现MSAP的危险因素(OR=1.121、3.716,P=0.025、0.001)。BAP组仅D-dimer升高是出现MSAP的危险因素(OR=2.717,P=0.002)。结论 CRP和D-dimer在HLAP及BAP中均随病情加重而升高,并且CRP升高在HLAP患者中更加明显。
Objective To investigate the changes of C-reactive protein（CRP） and D-dimer in the patients with hyperlipidemic acute pancreatitis（HLAP） and biliogenic acute pancreatitis（BAP）. Methods One hundred fifty-five inpatients with acute pancreatitis in our hospital from Jan. 2012 to Dec. 2014 were divided into the HLAP group and BAP group by etiology. Also the patients were divided into mild acute pancreatitis（MAP） subgroup and moderately severe acute pancreatitis（MSAP） subgroup by disease severity. Blood routine, liver and kidney function, glucose（Glu）, calcium, blood lipids, CRP and D-dimer were measured. Results Platelet,Glu and blood lipid indicators in the HLAP group were significantly higher than those in the BAP group. But alanine amin- otransferase（ALT）, r-glutamyl transferase （ GGT）, alkaline phosphatase（ ALP）, total bilirubin（ TBIL）, direct bilirubin（ DBIL）, calci- um（Ca） and creatinine（Cr） in the HLAP group were significantly lower than those in the BAP group（P〈0.05）. CRP in the HLAP group was significantly higher than that in the BAP group with statistical difference（P〈0.01）. CRP had statistical difference between the HLAP group and BAP group in the MAP and MSAP subgroups （P〈0.01）. CRP and D-dimer had statistical difference between in the MAP and MSAP subgroups of the HLAP group（P〈0.05）. Increased CRP and D-dimer in the HLAP group were the risk factors for MSAP occurrence（OR= 1. 121,3. 716,P=0. 025,0. 001）. In the BAP group,only increased D-dimer was the risk factor for MSAP occurrence（OR=2. 717,P=0. 002）. Conclusion CRP and D-dimer in HLAP and BAP are increased with disease severity aggravation,moreover CRP increase is more obvious in HLAP patients.
出处
《重庆医学》
CAS
北大核心
2017年第1期60-63,共4页
Chongqing medicine
基金
首都医科大学2015年度本科生科研创新项目(XSKY2015170)
