摘要
目的观察应用赛拉嗪联合右美托咪对建立比格犬脊髓损伤模型的麻醉效果。方法用随机数字表法将30只纯种雌性比格犬分为3组(n=10):赛拉嗪组(S组)、右美托咪定组(D组)、赛拉嗪+右美托咪定组(S+D组)。基础麻醉后,S组首次肌肉注射赛拉嗪0.08mL/kg,术中间断追加首次剂量1/3赛拉嗪维持麻醉,D组持续静脉注射右美托咪定2μg/(kg·h),S+D组持续静脉注射右美托咪定0.5μg/(kg·h),每隔30min肌肉注射赛拉嗪0.02mL/kg。观察记录切皮(T1)、手术开始后30min(T2)、手术结束前30min(T3)、手术结束(T4)4个时间点的心率(HR)、呼吸频率(RR)、Ramsay评分、前肢痉挛指数(SI),并记录麻醉药物使用量。结果 S+D组赛拉嗪、右美托咪定用量比S组和D组分别减少1/2和1/4(P<0.01),而呼吸频率和心率无明显改变,镇静效果优于S组,术中前肢未出现肌张力明显增高情况。结论赛拉嗪联合右美托咪定在用于建立比格犬脊髓损伤模型中,具有呼吸抑制轻、镇静效果好和减少麻醉药物用量等优点。
Objective To observe the anesthetic effects of xylazine and dexmedetomidin model of spinal cord injury in beagle dogs. Methods Thirty female beagle dogs were rand groups with 10 in each： xylazine group （group S）, dexmedetomidine group （group D dexmedetomidine group （group S＋D）. Basal anesthesia with ketamine was performed in all the e in establishing the omly divided into 3 ）, and xylazine ＋ dogs. Then group S was intramuscularly injected with xylazine discontinuously, group D was intravenously injected with dexmedetomidine 2 μg/（kg h） continuously, but group S＋ D was injected with xylazine and dexmedetomidine in combination. The heart rate （HR）, respiratory frequency （RR）, Ramsay score and spasm index （SI） were observed at the time of skin incision （T1）, after the beginning of the operation 30 rain （T2）, before the end of the operation 30 min （T3）, and the end of the operation（T4） ; and the usage of anesthetics was recorded. Results Compared with that in groups S and D, the usage of xylazine and dexmedetomidine in group STD was decreased by 1/2 and 1/4, respectively （P〈0.01）, but HR and RR did not change significantly; the sedative effect was superior to that in S. No obvious increase in muscular tensility in the foreleg was observed before operation. Conclusion Xylazine and dexmedetomidine used in combination to establish the model of spinal cord injury in beagle dogs have advantages of better sedative effect, less respiratory depression and lower dosage of anesthetic drugs.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2017年第1期147-150,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
武警后勤学院基础研究项目(No.WHJ2014016)~~
关键词
赛拉嗪
右美托咪定
脊髓损伤
比格犬
麻醉
镇静效果
xylazine
dexmedetomidine
spinal cord injury
beagle dog
anesthesia
sedative effect
