摘要
肝脏巨噬细胞在慢性肝损伤的发病机制中占有重要位置。肝脏巨噬细胞的抗原呈递功能缺陷,导致机体不能及时将抗原信号呈递给吞噬细胞,清除能力下降,最终导致免疫机制损伤,造成肝细胞炎性坏死。肝脏巨噬细胞具有异质性,可分为"具有促炎性作用的"M1巨噬细胞和"具有免疫调节作用的"M2型巨噬细胞,在肝脏出现损伤时可相互转化,肝脏巨噬细胞细胞最基本的功能是平衡持续不断的免疫刺激及产生免疫耐受。肝脏巨噬细胞表面表达抗原呈递分子,具有抗原呈递功能。本文重点介绍CD40、CD80、HLA-DR等抗原呈递分子在慢性肝损伤发病机制中的作用。
Liver macrophages play an important role in the pathogenesis of chronic liver injury.Antigen presentation dysfunction caused the body to be unable to present the antigen signal to the phagocytic cell in time,eventually leaded to immune mechanism damage.Hepatic macrophage heterogeneity can be divided into ＂promote inflammation＂ M1 macrophages and ＂immune regulation＂ M2 type macrophages.When the liver is damaged,it can be transformed into each other.The most basic function of hepatic macrophage cells is to balance the immune stimulation and immune tolerance.The hepatic macrophages expressed antigen presenting molecule,with the function of antigen presentation.This paper focuses on the role of CD40,CD80,HLA-DR and other antigen presenting molecules in the pathogenesis of autoimmune liver disease.
出处
《中国城乡企业卫生》
2016年第11期34-37,共4页
Chinese Journal of Urban and Rural Enterprise Hygiene
基金
2013年度滨海新区卫生局科技项目(2013BWKY017)
关键词
巨噬细胞
抗原呈递
慢性肝损伤
Macrophages
Antigen presentation
chronic liver injury
