摘要
目的：探讨新诊断2型糖尿病（T2DM）患者空腹血浆CTRP9水平变化及其与胰岛素抵抗（IR）的关系。方法：选取2015-01~2015-10在佳木斯大学附属第一医院内分泌科就诊的初诊T2DM肥胖患者30例为T2DM肥胖组（BMI≥28kg/m2）,及初诊T2DM非肥胖患者30例为T2DM非肥胖组（BMI〈24kg/m2）。以同期接受体检的健康者30例为对照组。收集各组一般临床资料,检测空腹血糖（FPG）、空腹胰岛素（FINS）用以计算胰岛素抵抗指数（HOMA-IR）,糖化血红蛋白（Hb A1C）、血脂指标、血清CTRP9和IL-6水平。T2DM肥胖组、T2DM非肥胖组、对照组之间比较采用方差分析,对CTRP9及其他因素进行单因素相关分析,和多元逐步回归分析。结果：1正常对照组CTRP9水平高于T2DM非肥胖组,T2DM非肥胖组CTRP9水平高于T2DM非肥胖组,而正常对照组、T2DM非肥胖组、T2DM肥胖组IL-6水平明显升高（P〈0.05）。2单因素相关分析显示血浆CTRP9与BMI、FPG、Hb A1C、TG、FINS、HOMA-IR及IL-6负相关,与HDL-C正相关（P〈0.01）。3以CTRP9为因变量行多元逐步回归分析,CTRP9水平与BMI、TG、HOMA-IR独立相关（P〈0.05）。结论：T2DM患者血清CTRP9水平降低可能参与了肥胖、糖脂代谢紊乱、炎症、胰岛素抵抗及糖尿病的发生、发展。
Objective：To explore the effect of C1 q/TNF- related protein 9 and insulin resistance （IR） in patients with newly diagnosed type 2 diabetes mellitus （T2DM）. Methods： In the department of Endocrinology, the First Affiliated Hospital of Jiamusi University from January to October 2015, 30 obese patients newly diagnosed as T2DM （obese group, BMI≥28 kg/m2） ,30 non- obese patients newly diagnosed as T2DM （non- obese group, BMI 〈 24kg/m2）, 30 healthy subjects （control group） were enrolled in this study. The general data was collected, and the levels of fasting blood glucose （FPG）FINS, insulin resistance index（HOMA- IR）, HbA1C, TC, TG, LDL -C, HDL- C, CTRP9 ,IL- 6 were calculated. Variance analysis was used to compare means. The correlation between CTRP9 and other factors were analyzed. Results： （1）The levels of CTRP9 reduced in control groups, obese, non - obese （P 〈 0. 05 ）, but the level of IL - 6 reduced （P 〈 0. 05 ）. （2）Single factor correlation analysis showed that the plasma level of CTRP9 had negative correlation with BMI,FPG,HbA1C,TG,FINS,HOMA -IR and IL - 6, and positive correlation with HDL - c （P 〈 0.01 ）. （3）Multiple linear regression showed that BMI, TG and HOMA- IR were independently associated with plasma CTRP9 level （P 〈 0.05）. Conclusion： The reduce of CTRP9 levels may be involved in obesity, glycolipid disorder, inflammation and the occurrence and development of IR and T2DM.
出处
《黑龙江医药科学》
2016年第6期94-96,共3页
Heilongjiang Medicine and Pharmacy
