摘要
目的探讨肝硬化合并胆囊结石的影响因素,为预防及治疗肝硬化合并胆囊结石提供参考依据。方法回顾性分析本院2015年10月至2015年12月收治的60例肝硬化合并胆囊结石患者(观察组)及60例肝硬化未合并胆囊结石患者(对照组)的临床资料。比较两组患者的年龄、性别比例、肝功能Child-Pugh分级、门静脉内径宽度、乙型肝炎表面抗原(HBsAg)、血清白蛋白(albumin,ALB)、总胆红素(total bilirubin,TBIL)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、肝硬化病因等的差异,分析肝硬化患者合并胆囊结石的危险因素,并采用多因素Logistic回归分析分析肝硬化患者合并胆囊结石的独立危险因素。结果两组患者年龄、性别比例、肝功能Child-Pugh分级、HBs Ag、TC水平及肝硬化病因比较差异均具有显著性(P<0.05或P<0.01);但两组患者门静脉内径宽度、TBIL、TG、ALB水平比较差异均无显著性(P>0.05)。多因素Logistic回归分析显示,年龄>58.3岁(OR=3.872,P<0.05)、女性(OR=4.117,P<0.01)、肝功能Child-Pugh分级C级(OR=4.019,P<0.01)及肝炎性肝硬化(OR=4.726,P<0.01)是肝硬化患者合并胆囊结石的独立危险因素。结论肝硬化合并胆囊结石的影响因素较多,对于年龄较大、肝功能较差、高TC水平及HBs Ag阳性的肝硬化患者,应积极进行干预,以期降低胆囊结石的发生率。
Objective To analyze the related factors of hepatocirrhosis complicated with gallstones, and to provide reference for the prevention and treatment of hepatocirrhosis complicated with gallstones. Method Retrospective analyzed the clinical data of 60 cases of patients with hepatocirrhosis complicated with gallstones （observation group） and 60 cases of patients with hepatocirrhosis but without gallstones （control group） in our hospital from October 2015 to December 2015. The age, gender, Child-Pugh grade, inside diameter of portal vein, HBsAg, albumin （ALB）, total bilirubin （TBIL）, total cholesterol （TC）, triglyceride （TO） and the reason of hepatocirrhosis were compared between the two groups, analyzed the risk factors of hepatocirrhosis complicated with gallstones. Logistic regression analysis was used to analyze the independent risk factors of hepatocirrhosis complicated with gallstones. Result There were significantly differences on age, gender, Child-Pugh, HBsAg, TC and reason of hepatocirrhosis between the two groups （P 〈 0.05, or P 〈 0.01）, and the inside diameter of portal vein, ALB, TBIL, TG and reason of hepatocirrhosis were identical between the two groups （P 〉 0.05）. Multi factor Logistic regression analysis showed that, age 〉 58.3 years old （OR = 3.872, P 〈 0.05）, female （OR = 4.117, P 〈 0.01） and grade C of Child-Pugh of liver function （OR = 4.019, P 〈 0.01） and reason of posthepatitic Cirrhosis （OR = 4.726, P 〈 0.01） were independent risk factors for hepatocirrhosis patients complicated with gallstones. Conclusion There are many factors affecting the hepatocirrhosis complicated with gallstone, and interventions must be taken in patients with old age, bad liver function, higher TC and positive HBsAg for decreasing the incidence of gallstones.
作者
李剑
LI Jian(Department of Hepatology, Tibetan Hospital of Qinghai Province, Xining 810007, China)
出处
《中国医学前沿杂志（电子版）》
2016年第11期97-100,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
