摘要
目的：观察短期胰岛素泵（CSII）强化治疗对初诊2型糖尿病（T2DM）患者血清 Betatrophin 水平的影响，探讨 Betatrophin 与胰岛素抵抗及胰岛β细胞功能的关系。方法：选取60例初诊 T2DM患者接受2周短期 CSII 强化治疗，所有研究对象于治疗前后均行口服葡萄糖耐量试验（OGTT）及胰岛素释放试验，并检测血脂及其他相关生化指标。采用 ELISA 法测定血清 Betatrophin 浓度。结果：CSII 治疗后血清 Betatrophin 水平为448．83（229．89～719．68）pg／mL，较治疗前明显升高[393．79（168．51～577．63）pg／mL，P ＜0．05]。相关分析结果显示，初诊 T2DM患者 CSII 治疗前血清 Betatrophin 与 HbA1c 呈正相关（r ＝0．320，P ＜0．05），与空腹血糖变化量（△Glu 0）、胰岛素抵抗指数变化量（△HOMA-IR）呈负相关（r 分别为－0．304、－0．266，P 均＜0．05）；CSII 治疗前后血清 Betatrophin 变化量（△Betatrophin）与空腹胰岛素差值（△Ins 0）、空腹 C 肽差值（△C-P 0）呈正相关（r 分别为0．282、0．307，P 均＜0．05）。以△Betatrophin 为因变量，△Ins 0、△C-P 0、△Glu 0、△HOMA-IR 为自变量建立多元逐步回归模型，结果显示△C-P 0（β＝172．03，P ＝0．016）进入方程（R2＝0．103，P ＜0．05）。结论：初诊 T2DM患者经短期 CSII 治疗后血清 Betatrophin 水平显著增高；且△C-P 0是△Betatrophin 的独立影响因素。
Objective：To investigate the effect of short-term continuous subcutaneous insulin infusion （CSII）on serum betatrophin in patients with newly diagnosed type 2 diabetes mellitus,and to study the relationships among betatrophin,and IR,pancreatic β-cell function.Methods：Sixty patients with newly diagnosed type 2 diabetes mellitus were treated with CSII for two weeks.Oral glucose tolerance test （OG-TT）,insulin releasing test,blood lipid and other relevant items were measured before and after therapy. Serum betatrophin level was determined with ELISA.Results：Two weeks of CSII treatment in T2DMre-sulted in significant elevation in serum betatrophin [393.79 （168.51 -577.63 ）pg/mL vs.448.83＆nbsp;（229.89 -719.68）,P 〈0.05].Correlation analysis showed that the serum betatrophin before treatment was positively correlated with HbA1c（r =0.320,P 〈0.05）,while negatively correlated with △Glu 0 （r =-0.304,P 〈0.05）and △HOMA-IR（r =-0.266,P 〈0.05）.The change of serum betatrophin （△Betatrophin）was positively correlated with △Ins 0（r =0.282,P 〈0.05）and △C-P 0（r =0.307, P 〈0.05）.Multiple stepwise regression analysis showed that △C-P 0 was the independent influencing factor for the △Betatrophin（β=172.03,P =0.016）.Conclusion：The concentration of serum betatro-phin was elevated after two weeks of CSII in newly diagnosed T2DM.The △C-P 0 was the independent related factor in the △Betatrophin.
作者
洪霞飞
薛灏颖
王苏
邓家良
马苏娴
于淑萍
杨奇超
杨玲
王东
尹卫
潘瑞蓉
周丽斌
袁国跃
HONG Xia-fei XUE Hao-ying WANG Su DENG Jia-hang MA Su-xian YU Shu-ping YANG Qi-chao YANG Ling WANG Dong YIN Wei PAN Rui-rong ZHOU Li-bin YUAN Guo-yue(Department of Endocrinology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001 Department of Endocrinology, the Affiliated Wujin Hospital of Jiangsu University, Changzhou Jiangsu 213002 Department of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China)
出处
《江苏大学学报（医学版）》
CAS
2016年第6期504-509,共6页
Journal of Jiangsu University：Medicine Edition
基金
国家自然科学基金资助项目(81570721
81370965)
江苏省自然科学基金资助项目(BK20151331
BK2009208)
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247)
"六大人才高峰"高层次人才项目(2015-WSN-006)
镇江市社会发展项目(SH2015028
SH2015042
SH2012027
SH2013035)
关键词
2
型糖尿病
胰岛素泵
Betatrophin
type 2 diabetes mellitu
continuous subcutaneous insulin infusion
Betatrophin
