摘要
目的：探讨Waldenstrom巨球蛋白血症（WM）的PET-CT表现及临床特点。方法：回顾性分析12例WM的临床特点、实验室检查结果及PET-CT表现。结果：12例WM的中位发病年龄为63.5岁,乏力及高粘滞综合征是其最常见的首发症状;所有患者骨髓弥漫性18^F-FDG摄取增高,SUVmax为4.9（2.1-21.9）;6例患者脾脏肿大,SUVmax为3.2（2.3-5.2）;6例患者淋巴结肿大,SUVmax为5.2（3.6-11.2）。脾脏、骨髓及淋巴结的SUVmax与白细胞计数、血红蛋白含量、血小板计数、β2-微球蛋白及血清单克隆Ig M均无相关性（P均〉0.5）。单因素分析显示,血清单克隆IgM及肿大淋巴结SUVmax与患者的预后相关（P〈0.5）。结论：WM的PET-CT表现具有一定的特征性,有助于个体化治疗方案的制定。
Objective：To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia（WM）.Methods：The clinical features,laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.Results：The average age of 12 patients with WM was 63.5 years old,the most common incipient symptoms were fatigue and hyperviscosity syndrome.The median SUVmax of bone marrow was 4.9（range of 2.1 to 21.9）,with diffusely increased F-FDG uptake in all the patients.In 6 patients,the median SUVmax of splenomegaly and lymphadenectasis was 3.2（range of 2.3 to 5.2） and 5.2（range of 3.6 to 11.2）,respectively.The SUVmax of bone marrow,splenomegaly and lymphadenectasis did not related with white blood cell count,hemoglobin level,blood platelet count,β2- microglobulin level and serum monoclonal IgM of such patients,respectively（both P 〉0.5）.In univariate analysis,serum monoclonal IgM and the SUVmax of lymphadenectasis were found to be the prognostic factors（both P〈 0.5）.Conclusion：The -（18）F-FDG PET-CT feature of Waldenstrom macroglobulinemia has some characteristics which are helpful for setting up the clinical therapeutic schedule.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2016年第6期1782-1786,共5页
Journal of Experimental Hematology
