摘要
目的评价1991-2015年中国肝硬化患者中酒精病因构成比的变化特点,并与部分发达国家地区相比较,为临床防治提供依据。方法检索Pubmed、CNKI、万方数据库、中国生物医学文献数据库等数据库中公开发表的、有关肝硬化病因分析的文献,通过Meta分析方法对入选的31篇相关文献进行汇总和分析,得出肝硬化患者酒精病因构成比的变化特点。结果 (1)近25年,中国肝硬化患者中酒精病因构成比为8.48%;2006-2015年中国肝硬化患者中酒精病因构成比高于1991-2005年(8.77%vs.7.04%,P<0.05);男性肝硬化患者中酒精病因构成比高于女性(13.05%vs.0.71%,P<0.05);东部地区肝硬化患者中酒精病因构成比高于西部地区(10.03%vs.5.86%,P<0.05)。(2)近25年,中国肝硬化患者中酒精病因构成比明显低于部分发达国家地区(8.48%vs.35.63%,P<0.05)。结论 (1)近25年中国肝硬化患者中酒精病因构成比变化总体呈上升趋势;且男性高于女性;东部地区高于西部地区;(2)近25年中国肝硬化患者中酒精病因构成比明显低于部分发达国家地区;(3)随着我国酒精消费的提高,国人酒精性肝硬化的发生率逐渐上升,提示临床工作人员需重视酒精性肝病的防治工作。
Objective To evaluate the characteristics of the constituent ratios of ALC（ alcoholic liver cirrhosis） in patients with liver cirrhosis in the past 25 years in China,and to compare the difference of constituent ratios between China and other countries. Methods Meta-analysis was used to summarize the data extracted from 31 related studies retrieved in Pubmed,CNKI,Wangfang and CBM. Results In the past25 years,the constituent ratio of ALC in patients with liver cirrhosis in China was 8. 48%. The constituent ratio in the study yeas of 2006-2015 was higher than of 1991-2005 in China（ 8. 77% vs. 7. 04%,P〈0.05）. It is higher in males than females（ 13. 05% vs. 0. 71%,P〈0.05） and in the eastern areas than in the western areas（ 10. 03% vs. 5. 86%,P〈0.05）. The constituent ratio of ALC in patients with liver cirrhosis in China was lower than other countries during the same period（ 8. 48% vs. 35. 63%,P〈0.05）. Conclusion The constituent ratio of ALC in patients with liver cirrhosis in China increased in the past 25 years. It was higher in males than females and in the eastern areas than in the western areas. And the constituent ratio in China was significantly lower than other countries during the same period. With the improvement of alcohol consumption in our country,the rate of alcoholic liver cirrhosis increased. As a medical worker,we should pay more attention to the prevention and treatment of alcoholic liver disease.
出处
《中华消化病与影像杂志（电子版）》
2016年第6期261-266,共6页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
肝硬化
病因
酒精性肝硬化
META分析
Liver cirrhosis
Etiology
Alcoholic liver cirrhosis
Meta-analysis
