摘要
丹参为唇形科鼠尾草属植物丹参的干燥根和茎,丹参酮是丹参的主要脂溶性成分,每一种丹参酮都有其特定的药理活性。针对各种丹参酮类化合物在心血管疾病、抗炎和免疫、抗肿瘤、肝保护、神经保护等多方面的国内外研究进展,该文总结了各种丹参酮对多种疾病的治疗作用及机理,综述了其药代动力学规律和制剂评价,为全面了解丹参酮类化合物,并根据其特点开发更为安全有效的药物提供了基础和保障。
Salvia miltiorrhiza bunge（ Dan shen in Chinese） is extracted from dried roots and rhizomes of Labiatae Salvia. Tanshinones are the main lipid-soluble components in Salvia,each has specific pharmacological activity. This review focuses on the research progress of Tanshinones on cardiovascular diseases,anti-inflammatory and immunomodulatory effects, anti-tumor effect,hepatocyte protection and neuroprotective effects. Therapeutic effects and mechanisms of Tanshinones on diverse diseases are summarized,pharmacokinetics and pharmaceutic evaluation were concluded. This review provides a global understanding about Tanshinones as a class of effective and promising candidates for further studies,and lays a foundation for developing new Tanshinone-based agents according to the characteristics of Tanshinones.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2016年第12期1643-1647,共5页
Chinese Pharmacological Bulletin
基金
国家优秀青年科学基金资助项目(No 81522007)
关键词
丹参酮
临床应用
药理作用
药效机制
药代动力学
制剂评价
Tanshinones
clinical appacation
pharmacologic effects
therapeutic mechanism
pharmacokinetics
pharmaceutic evaluation
