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晨尿尿蛋白/尿肌酐比值评估狼疮性肾炎患者尿蛋白的效果 被引量:4

Effect of urine protein to creatinine ratio on assessment of proteinuria in patients with lupus nephritis
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摘要 目的探讨狼疮性肾炎(LN)患者采用晨尿尿蛋白/尿肌酐比值(UPCR)预测24 h尿蛋白定量的有效性。方法纳入本院风湿免疫科住院治疗的LN患者136例,根据24 h尿蛋白定量、血清肌酐水平分为亚组,将患者UPCR与24 h尿蛋白定量行Pearson相关性分析,采用受试者工作曲线(ROC曲线),根据最佳敏感性和特异性确定UPCR诊断界点。结果晨尿UPCR和24 h尿蛋白定量呈显著正相关(r=0.899,P<0.01)。24 h尿蛋白定量为0.5、1.0、2.0、3.0、4.0和5.0 g对应的UPCR诊断界值分别为0.4、1.0、2.04、2.44、3.37和4.65。结论晨尿UPCR与24 h尿蛋白定量具有良好的相关性。 Objective To explore the accuracy and utility of urine protein to creatinine ratio (UPCR) in predicting 24 h urinary protein quantitation of patients with lupus nephritis (LN). Meth- ods One hundred and thirty six LN patients were enrolled. The correlation between the UPCR in the morning spot urine samples and urinary protein excretion in the 24-hour collections was examined by the Pearson correlation test between sub-groups of different urinary protein excretion and serum creati- nine levels. The best cutoffs for UPCR in predicting a 24-hour protein excretion were determined with the receiver operating characteristic curve (ROC). Results The data showed a good positive corre- lation between the UPCR and 24-hour protein excretion ( r = 0. 899, P 〈 0.01 ). The best cutoffs were 0.4 for 0.5 g, 1.0 for 1.0 g, 2.04 for 2.0 g, 2.44 for 3.0 g, 3.37 for 4.0 g and 4.65 for 5.0 g. Conclusion Morning urine UPCR and 24 h urine protein quantitative has a good correlation.
出处 《实用临床医药杂志》 CAS 2016年第23期47-49,共3页 Journal of Clinical Medicine in Practice
基金 国家自然科学基金(81671608,81202350,81571586)
关键词 狼疮性肾炎 尿蛋白/尿肌酐比值 24 h尿蛋白定量 lupus nephritis urine protein to creatinine ratio 24 h urinary protein quanti-ration
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