摘要
目的探讨结缔组织病合并肺动脉高压及妊娠患者的临床特点、诊疗关键。方法本文回顾分析2013—2015年期间我院收治的3例伴有重度肺动脉高压的结缔组织病合并妊娠死亡病例的临床资料。结果 2例基础病为系统性红斑狼疮,1例为混合结缔组织病;3例患者发现肺动脉高压时均合并妊娠,均死亡,1例在妊娠20周死亡,2例产后死亡。死亡原因包括肺动脉高压危象,室性心律失常。结论肺动脉高压是结缔组织病的严重并发症之一,结缔组织病相关肺动脉高压患者一旦妊娠,死亡率高。对此类患者强调早期诊断及教育,避免妊娠,在孕早期及时终止妊娠。
Objective To describe the clinical characteristics and therapy in severe pulmonary arterial hypertension （PAH） associated with connective tissue disease （CTD） during pregnancy. Method The charts of 3 pregnant women with severe CTD-PAH during 2013--2015 were reviewed to assess the multidisciplinary treatment and outcome of these patients. Result There were 2 cases of systemic lupus erythematosus associated PAH and 1 case of mixed connective tissue associated PAH. These 3 patients first presented with PAH during pregnancy were not rescued successfully. One patient died before delivery at 20 weeks＇ gestation and two died postpar^rn. The causes of death included pulmonary arterial hypertension crisis and ventricular arrhythmias. Conclusion Pulmonary hypertension is one of the most serious complications of connective tissue disease. Pregnancy in patients with CTD-PAH is associated with a high maternal mortality. Thus, focus should be placed on early diagnosis of CTD-PAH and women with CTD- PAH should be counseled to terminate an early pregnancy or avoid pregnancy.
作者
高飞
林禾
GAO Fei LIN He(Department of Immunology and Rheumatology, Fujian Provincial Hospital, Fuzhou 350001,China)
出处
《创伤与急诊电子杂志》
2016年第3期138-140,共3页
Journal of Trauma and Emergency(Electronic Version)
关键词
高血压
肺性
结缔组织病
妊娠
Hypertension,Pulmonary
Connective tissue disease
Pregnancy
