摘要
目的比较连续性肾脏替代治疗（CRRT）与常规疗法对重症感染引起急性肾损伤患者临床效果及血清炎性介质的影响。方法将2015年8月-2016年8月广东省佛山市高明区人民医院收治的70例重症感染引起急性肾损伤患者，随机分为两组，各75例。对照组患者给予常规治疗，观察组患者给予CRRT。比较两组患者治疗前后的肾功能指标、血清炎性因子水平、病死率及急性生理与慢性健康Ⅱ（APACHEⅡ）评分。结果观察组治疗后的血肌酐、血尿素氮、血钾和血乳酸水平明显低于治疗前和对照组治疗后（P〈0．05）：观察组治疗后的肿瘤坏死因子-α、白介素-4、白介素-6和白介素-10水平明显低于治疗前和对照组治疗后（P〈0．05）；治疗后观察组患者的病死率及APACHEⅡ评分明显低于对照组（P〈0．05）。结论CRRT可明显改善重症感染引起急性肾损伤患者的肾功能指标和血清炎性因子水平，降低病死率。
Objective To compare the inflerence of continuous renal replacement therapy and conventional therapy on clinical effect and serum inflammatory factors of patients with acute kidney injury caused by severe infections. Methods From August 2015 to August 2016, in Gaoming People＇s Hospital of Foshan, 70 patients with acute kidney injury caused by severe infections were divided into two groups randomly, each group had 35 cases. The control group was given conventional therapy and the observation group was given continuous renal replacement therapy. The renal function index, inflammatory factor levels, mortality rate and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） scores of patients in two groups were compared. Results Serum creatinine, blood urea nitrogen, blood potassium and blood lactic acid in the observation group after treatment were significantly lower than before treatment and the control group after treatment （P 〈 0.05）. The levels of TNF-α, IL-4, IL-6 and IL-10 in the observation group after treatment were significantly lower than before treatment and the control group after treatment （P 〈 0.05）. Mortality rate and APACHE 11 scores in the observation group after treatment were significantly lower than the control group after treatment （P 〈 0.05）. Conclusion Continuous renal replacement therapy can effectively improve renal function index, inflammatory factor levels and reduce mortality rate.
作者
李敏雄
黄永鹏
叶燕红
伍增龙
庞荣锋
范小龙
LI Minxiong HUANG Yongpeng YE Yanhong WU Zenglong PANG Rongfeng FAN Xiaolong(Department of Intensive Care Unit, Gaoming People＇s Hospital of Foshan, Guangdong Province, Foshan 528500, Chin)
出处
《中国医药导报》
CAS
2016年第34期81-84,共4页
China Medical Herald
关键词
连续性肾脏替代疗法
重症感染
急性肾损伤
血清炎性因子
Continuous renal replacement therapy
Severe infections
Acute kidney injury
Serum inflammatory factor
