摘要
目的：评估稳定型冠心病患者焦虑抑郁与 C 反应蛋白（CRP）、肌钙蛋白 T（TnT）以及氨基端前-B 型脑钠素（NT-proBNP）之间的关系。方法120例稳定型冠心病门诊患者，共四组：冠心病合并抑郁症组（MDD 组）、冠心病合并焦虑症组（GAD 组），冠心病合并虑症抑郁组（MDD ＋GAD 组）及无精神障碍冠心病组，每组各30例。比较四组患者 CRP、TnT 及 NT-proBNP 的差异，并应用 Logistic 回归分析探索三者与焦虑抑郁之间的关系。结果 MDD 组、GAD 组、MDD ＋GAD 组的 CRP 水平[分别为：（8．5±1．2）mg／L、（6．7±1．7）mg／L、（7．6±1．4）mg／L]均明显高于无精神障碍组的（5．1±2．4）mg／L（t ＝6．940，P ＜0．001；t ＝2．978， P ＝0．004；t ＝4．928，P ＜0．001）。Logistic 回归分析显示，CRP 水平与 GAD（P ＝0．04）、MDD（P ＝0．03）、MDD ＋GAD（P ＝0．03）以及受教育程度（P ＝0．004）之间显著相关；TnT 水平与高血脂（P ＝0．009）、肥胖或超重（P ＝0．04）和受教育程度（P ＝0．04）之间显著相关。NT-proBNP 水平和2型糖尿病显著相关（P ＝0．005）。结论 CRP 水平与稳定型冠心病合并焦虑抑郁障碍显著相关，可以此为依据对冠心病患者焦虑抑郁情绪进行识别，及时治疗。
Objective To analyze the correlation between C -reactive protein （CRP）,troponin T （TnT）, NT -proBNP and anxiety and depression in patients with stable coronary heart disease （CHD ）.Methods 120 patients with stable CHD were divided into 4 groups：CHD with major depressive disorder （MDD）,CHD with general anxiety disorder （GAD）,CHD with MDD and GAD,CHD without mental disorders,and 30 cases in each group.CRP,TnT and NT -proBNP were compared among 4 groups,and the logistic regression analysis was applied to explore the relationship between them and anxiety/depression.Results The CRP levels in MDD group （8.5 ± 1.2）mg/L,GAD group （6.7 ±1.7）mg/L,MDD ＋GAD group （7.6 ±1.4）mg/L were significantly higher than those without mental disorders group （5.1 ±2.4）mg/L （t =6.940,P 〈0.001;t =2.978,P =0.004;t =4.928,P 〈0.001）.Logistic regression showed that CRP level was significantly correlated with GAD （P =0.04）,MDD （P =0.03）,MDD ＋GAD （P =0.03）,as well as education level （P =0.004）.The TnT level was correlated with hyper-lipidemia （P =0.009）,obesity/overweight （P =0.04）and educational level （P =0.04）.NT -proBNP was signifi-cantly related with type 2 diabetes （P =0.005）.Conclusion CRP level is significantly associated with anxiety and depression in patients with stable CHD.CRP can be used to screen for anxiety and depression,and to provide timely treatment.
作者
杨继敏
苏亚玲
Yang Jimin Su Yaling(Department of Cardiology,Miyun Teaching Hospital of the Capital Medical University, Beijing 101500, China)
出处
《中国基层医药》
CAS
2016年第24期3781-3785,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
C反应蛋白质
焦虑
抑郁
冠状动脉疾病
C -reactive protein
Anxiety
Depression
Coronary artery disease
