摘要
【提要】多结节肝细胞癌可分为多中心发生及肝内转移两种形式。源于基因组学、转录组学或蛋白质组学研究的不同诊断策略，不但可明确肝癌的克隆起源，而且有可能获得治愈肝癌的方法。本文对乙肝病毒（HBV）DNA整合、p53突变、染色体杂合性缺失、线粒体D—Loop区突变、蛋白质组学等判断肝癌起源的方法做一综述，以便了解各种方法的适用范围及进展。并根据文献总结不同起源模式的肝癌预后情况。目前认为与多中心发生肿瘤相比，肝内转移型肝癌预后更差。
Based on the pathogenetic occurrence of the tumor, multinodular hepatocellular carcinoma can be classified into muhicentric occurrence and intrahepatic metastasis. Diffe- rent diagnostic strategies from genomics, transcriptomics and proteomics can be used to define the clonal origin of tumors and provide advisable method to cure the disease. Pathomorphologi- cal test was ＂ gold standard＂ in cancer diagnosis at one time. Currently, from the respect of molecular diagnosis, including HBV DNA intergration, p53 mutation, selective X chromosome inactivation, loss of heteozygosity of chromosomal DNA, mtDNA-Loop, transcriptional sequence, and comparative pro- teomics, we could accurately differentiate the clonal origin of tumors. Intrahepatic metastasis was demonstrated with a high early recurrence rate and low survival rate comparing to the mul- ticentric occurrence from the review of the previous study.
作者
章蔚
严律南
Zhang Wei Yah Lyunan.(Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2016年第12期854-858,共5页
Chinese Journal of Hepatobiliary Surgery
关键词
多结节肝癌
多中心发生
肝内转移
分子诊断
预后
Muhifocal hepatocellular carcinoma
Muhicentric occurrence
Intrahepatic metastasis
Molecular diagnosis
Prognosis
