摘要
目的分析山东省50岁及以上首次接受艾滋病免费抗病毒治疗的HIV感染者和艾滋病患者抗病毒治疗情况。方法收集2003-2014年底在山东省内接受艾滋病抗病毒治疗的50岁及以上HIV感染者和艾滋病患者基线和治疗后的相关资料,分析抗病毒治疗效果。结果共纳入研究对象322例,其中男性占76.7%,女性占23.3%;平均年龄为(56.9±6.4)岁;以已婚或同居者为主,占63.4%;感染途径以异性性传播为主,占54.3%;基线时CD4^+T淋巴细胞计数中位数是194.0(83.5~301.0)个/mm^3,基线时仅不同感染途径者CD4^+T淋巴细胞计数差异有统计学意义(H=14.200,P=0.003)。治疗后不同时间段与基线时CD4^+T淋巴细胞计数进行比较,显示差异均有统计学意义(均有P<0.001),多因素分析结果显示性别和治疗前机会性感染情况是影响治疗效果的因素(均有P<0.05)。治疗后不同时间段病毒完全抑制的比例差异无统计学意义(X^2=2.093,P=0.719)。结论山东省50岁以上的HIV感染者和艾滋病患者接受艾滋病抗病毒治疗能有效提高机体免疫力,降低病毒载量。
Objective To analyze the results of antiretroviral therapy among HIV/AIDS patients aged above 50 years in Shandong Province. Methods A face-to-face interview was conducted to collect baseline and after treatment data among HIV/AIDS patients aged above 50 years who started antiretroviral therapy in Shandong province during 2003 to 2014. The CD4^＋ T cell count and viral load were analyzed to evaluate the effect of antiretroviral therapy. Results Of the 322 patients, 76. 7% were male and 23.3% were female. The average age was （56.9±6. 4） years old. 63.4% were married or cohabiting. Heterosexual transmission was the major transmission route, accounting for 54. 3%. The median of CD4^＋ T cell count was 194. 0 （83.5±301.0） on baseline, and there was significant difference in CD4＋ T cell count among HIV/AIDS patients by different transmission route （ H = 14. 200, P = 0. 003 ）. CD4^＋ T cell count of different time points after treatment showed differences compared with the baseline data（ all P 〈 0. 001 ）. The Logistic analysis showed that gender and opportunistic infections status before treatment were the influencing factor of therapeutic effectiveness （ all P 〈 0. 05 ）. There was no significant difference among the proportion of complete inhibition of virus at different time periods （ χ^2 = 2. 093, P = 0. 719）. Conclusions The antirctroviral therapy can effectively improve the body immunity, reduce viral load of HIV/AIDS in patients aged above 50 years in Shandong Province.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2016年第12期1199-1202,1207,共5页
Chinese Journal of Disease Control & Prevention
基金
山东省医药卫生科技发展计划项目(2013WS0166)
