摘要
目的：对比剂剂量（CMV）与肌酐清除率（CrCl）比值预测冠脉介入诊疗术后对比剂肾病（CIN）的价值。方法：2009年4月至2013年12月纳入3670例于广东省人民医院行冠脉介入诊疗（CAG±PCI）患者。受试者工作特征曲线分析CMV／CrCl最佳临界值。多因素Logistic分析CMV／CrCl与CIN相关性。结果：CIN发生率是3．22％。CMV／CrCl预测CIN的最佳临界值为2．88，特异度为79．8％．灵敏度为63．2％。CMV／CrCl≥2．88组CIN发生率显著高于CMV／CrCl〈2．88组（9.4％V31．7％．P〈0．001）。多因素Logistic分析显示CMV／CrCl≥2．88与CIN显著独立相关（OR：2．12，95％CI：1．21～3．70，P=0．008）。结论：CMV／CrCl是预测冠脉介入诊疗术后CIN的有效指标。
Objective To investigate the predictive value of contrast medium volume （CMV） and creatinine clearance （CrCl） ratio （CMV/CrCl） in contrast induced nephropathy （CIN） after pereutaneous coronary artery angiography and intervention （CAG/PCI）. Methods 3 670 patients undergoing CAG/PCI admitted to Guangdong General Hospital from April 2009 to December 2009 were consecutively enrolled in this study. Receiver operating characteristic curve （ROC） were used to obtain a best cut-off point of CMV/CrC1 to predict CIN. The correlation between CMV/CrC1 and CIN was analyzed with multivariate logistic regression. Results The incidence of CIN was 3.22%. ROC curve analysis showed that the cut-off point of CMV/CrCl was 2.88. The incidence of CIN in CMV/CrCl≥ 2.88 group was significantly higher than CMV/CrCl〈2.88 group （9.4% vs. 1.7%, P 〈 0.001）. Multivariate logistic regression analysis showed that CMV/CrCl≥2.88 was still associated with CIN incidence （OR： 2.12, 95% CI： 1.21 - 3.70, P = 0.008） after confounding factors adjustment. Conclusion CMV/CrCl was a good predictive indicator of CIN after CAG/PCI.
出处
《实用医学杂志》
CAS
北大核心
2016年第23期3882-3885,共4页
The Journal of Practical Medicine
关键词
对比剂剂量
肌酐清除率
对比剂肾病
Contrast medium volume
Creatinine clearance
Contrast induced nephropathy
