摘要
目的研究血清胰岛素样生长因子-1(IGF-1)在预测早产儿高胆红素血症和评价光疗效果中的临床意义。方法选择36例早产儿为研究对象。记录出生第1天IGF-1水平、血清总胆红素峰值及光疗持续时间。同时观察每个早产儿对光疗初始治疗的反应性。若早产儿行脑核磁共振检查,分析并记录检查结果。结果出生第1天血清IGF-1的水平与血清胆红素峰值无明显相关性,但与光疗持续时间呈明显负相关(r=-0.7003,P<0.05)。光疗初始反应敏感患儿的IGF-1明显高于对光疗初始反应不敏感的患儿(39.6±17.7μg·L^(-1)vs 21.1±13.2μg·L^(-1),P<0.05)。3例早产儿发现苍白球T1W1异常信号改变,其血清IGF-1值明显低于苍白球正常信号组早产儿(10.8±0.4μg·L^(-1)vs 13.4±2.2μg·L^(-1),P<0.05)。结论早产儿IGF-1的水平并不能预测早产儿血清总胆红素峰值,但IGF-1水平越高,需要光疗持续时间越短,光疗初始治疗越敏感,提示IGF-1水平与机体胆红素处理能力的恢复相关。IGF-1水平低下的早产儿越易出现急性胆红素脑病。
Objective To investigate the clinical significance of IGF-1 on prediction and evaluation of phototherapy treatment in the hyperbilirubinemia of premature neonates. Methods The premature neonates in the NICU were enrolled randomly. Serum IGF-1 level was tested and recorded on the first day after birth. The peak values of TSB and the duration of phototherapy were also recorded. The responses to the initial phototherapy of the premature neonates were observed respectively. The results of brain MRI were analyzed if the MRI examination was executed in the premature neonates. Results A total of 36 cases were collected. No significant correlation was found between the IGF-1 levels and the peak values of TSB. However,the serum IGF-1 level was negatively correlated with the duration ofphototherapy obviously（ r =- 0. 7 0 0 3,P〈0. 0 5）. Serum IGF-1 level in the sensitive group to the initial phototherapy was significantly
出处
《安徽医药》
CAS
2016年第10期1915-1918,共4页
Anhui Medical and Pharmaceutical Journal
基金
安徽医科大学校临床科学研究项目(2015xkj104)
