摘要
目的了解江苏省健康儿童脊髓灰质炎（脊灰）中和抗体水平,评价江苏省儿童脊灰减毒活疫苗免疫效果。方法收集江苏省2011-2015年14岁以下健康儿童血清样本,应用细胞中和实验方法检测脊灰中和抗体。使用SPSS 20.0统计软件进行统计分析。结果共检测2 000名健康儿童的血清样本,脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为98.55%、98.25%、95.15%;几何平均滴度（GMT）分别为1∶154.88、1∶75.86、1∶31.62。3种型别脊灰中和抗体GMT各年龄组间差异有统计学意义,均为1～岁组最高,随着年龄的增长有下降的趋势。不同免疫史次数儿童的脊灰抗体水平差异也均有统计学意义,完成3次免疫的儿童中和抗体GMT最高。结论江苏省保持了高水平的脊灰疫苗免疫覆盖率,对儿童脊髓灰质炎起到良好的免疫保护作用。值得注意的是脊灰中和抗体几何平均滴度总体呈逐年下降的趋势,需引起相关部门的重视。
Objective To measure the levels of neutralized antibody to poliovirus among healthy children in Jiangsu province of China during the period of 2011 to 2015and evaluate the efficacy of the oral poliovirus vaccines（OPV）. Methods Healthy children under 14 were randomly enrolled from Jiangsu province of China.The poliomyelitis antibody levels were detected by cell neutralization test.SPSS 20.0software was used for statistical analysis. Results Of the 2 000 serum specimen collected,the neutralizing antibody positive rates for polioⅠ,Ⅱ,and Ⅲ were 98.55%,98.25% and 95.15%,respectively;the geometric mean antibody titers（GMTs）were 1∶154.88,1∶75.86 and 1∶31.62 respectively.The serum neutralization antibodies to polio were significantly associated with ages and the history of immunization（P〈0.05）.The GMTs of polio neutralized antibodies reduced as the age increases,and the GMTs of the children who accepted three times of immunization were higher than that of others. Conclusions The poliomyelitis antibody positive rates and GMTs are still maintaining a high-level and show good immune protection against polio in Jiangsu province of China.But the GMTs of poliomyelitis antibody showed a decreasing trend with the years.
作者
吴昀
冷红英
陈勇
陈强
毕诚
WU Yun LENG Hong-ying CHEN Yong CHEN Qiang BI Cheng(Center for Disease Control and Prevention of Jiangsu Province, Nanjing, Jiangsu223002, Chin)
出处
《中国病毒病杂志》
CAS
2016年第4期284-287,共4页
Chinese Journal of Viral Diseases
基金
江苏省卫生计生委科研课题(H201515)
