摘要
目的探讨全容积实时三维超声容积-时间曲线参数早期诊断阿霉素(ADM)致兔心肌损伤及心力衰竭的价值。方法对12只新西兰大白兔每周静脉注射ADM 2mg/kg体质量,分别于注射前(A组)、注射后2周(B组)、4周(C组)、6周(D组)进行超声检查,每组兔注射ADM的总剂量为0、4、8、12mg/kg体质量。采用二维超声于左心室长轴切面舒张期末测量左心房、左心室前后径,采用三维超声测量左心室舒张期末容积(EDV)、左心室收缩期末容积(ESV),计算射血分数(EF)。获取17个心肌节段在1个心动周期的左心室容积-时间变化曲线、左心室整体功能参数成像"饼图",以及左心室16节段不同步参数,包括达最小收缩容积的时间标准差(Tmsv16-SD)、最大时间差值(Tmsv16-Dif),及经心动周期的校正值Tmsv16-SD%、Tmsv16-Dif%。超声检查完毕后进行病理学检查。结果 4组间Tmsv16-SD、Tmsv16-Dif、Tmsv16-SD%、Tmsv16-Dif%及EF值差异有统计学意义(P均<0.05),其中D组与A、B、C组比较差异有统计学意义(P均<0.05),C组与A、B组比较差异有统计学意义(P均<0.05),A组与B组间差异无统计学意义(P>0.05);EF值D组与A组间比较差异有统计学意义(P<0.05)。病理改变主要为心肌细胞空泡变性,B组局限于心内膜下心肌,C组达中层心肌,D组达心外膜下心肌。结论全容积三维超声在心力衰竭早期阶段即可检出兔左心室不同步参数的变化,为检测心肌损伤及早期心力衰竭提供有价值的参考。
Objective To investigate the early diagnostic value of full volume three-dimensional echocardiography （3DE） parameters in adriamycin （ADM）-induced rabbit myocardial injury and heart failure. Methods ADM were injected in 12 New Zealand white rabbits every week with the dose of 2 mg/kg. The ultrasonography was perfomed before the injection （group A）, 2 weeks （group B）, 4 weeks （group C）, and 6 weeks （group D） after injection. And the total dose of ADM in every group were 0, 4, 8 and 12 mg/kg. The anteroposterior diameter of end-diastolic left atrial （LA） and left ventricular （LV） were measured in left ventricular long axis view by two-dimensional echocardiography. The end-diastolic volume （EDV） of LV, the end-systolic volume （ESV） of LV and ejection fraction （EF） were measured or calculated by 3DE. Also the 17 segmental myocardial volume-time curve of LV, the LV global function parametric imaging ＂Pie chart＂ and the asynchronous parameters of 16 segments including standard deviation of time to minimal systolic volume （Tmsv16-SD）, differ- ence of time to maximum systolic volume （Tmsv16-Dif）, and the correction value by one cardiac cycle （Tmsv16-SD%, Tmsv16-Dif%） were obtained. The pathologic changes of myocardium were observed after echocardiography. Results There were significant differences of all the asynchronous parameters （Tmsv16-SD, Tmsv16-Dif, Tmsv16-SD%, Tmsv16- Dif%） and EF among 4 groups （all P〈0.05）. The asynchronous parameters of group D were higher than those of group A, B, and C （all P〈0.05）, of group C was higher than those of group A and B （all P〈0.05）, of group A and B had no significant difference （all P〉0. 05）. There was significant difference of EF between group D and A （P〈0.05）. The main pathological change was vacuolar degeneration in myocardial cell, the damage range was located in the subendocardial myo- cardium in group B, reached the middle myoeardium in group C, and increased to the epicardial myo
作者
刘学兵
尹立雪
邓燕
张清凤
陆景
LIU Xuebing YIN Lixue DENG Yan ZHANG Qingfeng LU Jing(Department of Cardiovascular Ultrasound＆ Non-invasive Cardiology, Sichuan Province People＇s Hospital, Chengdu 610072, China)
出处
《中国医学影像技术》
CSCD
北大核心
2016年第12期1833-1837,共5页
Chinese Journal of Medical Imaging Technology
基金
四川省卫生厅科研课题项目(130157)
关键词
超声心动描记术
三维
容积-时间曲线
心力衰竭
阿霉素
动物实验
Echocardiography, three-dimensional
Volume-time curve
Heart failure
Adriamycin
Animal experimentation
