摘要
目的探讨双泛素(FAT10)和核因子-κB p50(NF-κB p50)在乳腺浸润性导管癌中的表达及其与临床病理特征的关系。方法应用Max VisionTM免疫组织化学法,检测112例乳腺浸润性导管癌组织和53例癌旁组织中FAT10与NF-κB p50的表达,并分析两者表达的相关性及其与乳腺癌临床病理特征的关系。结果 FAT10和NF-κB p50在乳腺浸润性导管癌中的阳性表达率分别为77.68%(87/112)和81.25%(91/112),明显高于癌旁组织的39.62%(21/53)和45.28%(24/53),差异均有统计学意义(P<0.001)。FAT10、NF-κB p50在乳腺浸润性导管癌中的表达与淋巴结转移、远处转移及TNM分期有关(P<0.05),而与患者的年龄、肿瘤大小及分子分型无关(P>0.05)。FAT10与NF-κB p50在乳腺浸润性导管癌中的表达呈显著正相关(r=0.624,P<0.001)。结论 FAT10、NF-κB p50的表达与乳腺浸润性导管癌的恶性程度及侵袭转移密切相关,两者可能共同促进肿瘤的发生发展。
Objective To investigate the expression of human leukocyte antigen F-associated transcript 10 （FAT10） and nu- clear factor KB p50（ NF-KB p50） in infiltrating ductal carcinoma of breast, and their relationship with clinicopathological characteris- tics. Methods FAT10 and NF-KB p50 expression in 112 patients with infiltrating ductal carcinoma of breast and in 53 breast non-can- cerous tissues were measured by immunohistochemistry. The relationship between FAT10, NF-KB pS0 expression and clinicopathological features of infiltrating ductal carcinoma of breast were analyzed. Results The positive rate of FAT10 and NF-KB p50 expression in infiltrating ductal carcinoma of breast was 77.68% （87/112） and 81.25% （91/112） respectively, significantly higher than 39. 62% （21/53）and 45.28% （24/53）in the non-cancerous tissues, and the difference was statistically significant （P〈 0. 001 ）. The expression of FAT10, NF-KB p50 was related to lymph node metastasis, distant metastasis and TNM stages of infiltrating ductal carcinoma of breast（P〈0. 05）. But they had no obvious relation to age, tumor size and molecular type（P〉0. 05）. The expres- sion of FAT10 was positively correlated with the expression of NF-κB p50 （r = 0. 624, P〈0. 001 ）. Conclusion The expression of FAT10, NF-κB p50 is closely associated with malignancy and invasive metastasis of infiltrating ductal carcinoma of breast. They may together promote tumor＇s occurrence and development.
出处
《临床肿瘤学杂志》
CAS
2016年第11期972-975,共4页
Chinese Clinical Oncology
基金
昆明医科大学2016年硕士研究生创新基金立项项目(2016S110)
