摘要
目的分析血清脂蛋白相关磷脂酶A2(Lp-PLA2)与总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)5项传统冠心病指标的相关性,探讨其浓度与冠状动脉病变及病变程度的关系。方法选取200例确诊冠心病患者设为病变组(病变组又分为单支病变、双支病变和三支病变),同时选取同期健康体检者100例为对照组,对Lp-PLA2与TC、TG、LDL-C、hs-CRP、Hcy 5项传统指标进行相关性分析,比较Lp-PLA2浓度在病变组和对照组差异及与冠状动脉病变支数的关系。结果 Lp-PLA2与LDL-C、Hcy、TC和hs-CRP显著相关(均P<0.05),与TG无相关(P>0.05),病变组Lp-PLA2浓度明显高于对照组(P<0.01),其浓度随着冠状动脉病变支数的增加而升高,但相关性不显著(P>0.05)。结论高浓度Lp-PLA2是冠状动脉粥样硬化的危险因素,其浓度与冠状动脉病变程度的相关性还需进一步研究。
Objective To analyze the correlation between serum lipoprotein associated phospholipase A2（Lp-PLA2）with five traditional inflammatory factors of TC,TG,LDL-C,hs-CRP and Hcy in the patients with coronary heart disease（CHD）,and to investigate the relationship between its concentration with the lesions and severity of CHD.Methods Two hundreds cases of CHD were selected as the lesion group（which was subdivide into single vessel lesion,double vessel lesion and three vessel lesion）,at the same time,100 persons undergoing physical examination were selected as the control group.The correlation between Lp-PLA2 with five traditional inflammatory factors of TC,TG,LDL-C,hs-CRP and Hcy was analyzed.The differences of Lp-PLA2 in the lesion group and the control group were compared and the relation between Lp-PLA2 level with lesion vessels number was analyzed.Results Lp-PLA2 was significantly correlated with LDL-C,Hcy,TC and hs-CRP（P〈0.05）and had no relation with TG（P〈0.05）,the level of Lp-PLA2 in the lesion group was significantly higher than that in the control group（P〈0.01）,the Lp-PLA2 level was elevated with the number of coronary lesion vessels,but the correlation is unobvious（P〈0.05）.Conclusion High concentration of Lp-PLA2 is a risk factor for coronary atherosclerosis,but the correlation between the Lp-PLA2 level and the severity of coronary arterial lesion needs further study.
出处
《国际检验医学杂志》
CAS
2016年第23期3306-3307,3310,共3页
International Journal of Laboratory Medicine
关键词
冠心病
动脉粥样硬化
脂蛋白相关磷脂酶A2
coronary heart disease
atherosclerosis
lipoprotein associated phospholipase A2
