摘要
目的:研究归脾汤结合耳穴埋豆治疗卒中后失眠的疗效及对血清TNF-α水平的影响。方法:将医院收治的70例卒中后失眠患者,随机分为试验组和对照组,试验组患者采用归脾汤(加减)+耳穴埋豆治疗,对照组患者应用归脾汤(加减)治疗,治疗4周,比较两组患者匹兹堡睡眠质量指数(PSQI)评分、血清TNF-α水平。结果:治疗4周后,试验组有效率为91.43%(32/35),对照组为71.43%(25/35),差异具有统计学意义,P<0.05;两组治疗后PSQI各项指标评分及总评分较治疗前明显下降,差异均有统计学意义,P<0.05;但试验组在睡眠质量、睡眠时间、日间功能障碍及总评分方面较对照组下降明显,差异有统计学意义,P<0.05;两组治疗后血清TNF-α水平较治疗前明显上升,但试验组上升更明显,有统计学差异,P<0.05,且PSQI评分与患者血清TNF-α水平呈明显的负相关性;两组患者治疗期间均无不良反应发生。结论:归脾汤结合耳穴埋豆能明显提高卒中后失眠患者临床疗效,较好改善睡眠质量,其机制可能与其能更好地调节血清TNF-α水平有关。
Objective：To investigate the effect of Guipi Decoction and auricular beans therapy on post-stroke insomnia and serum TNF-α levels.Methods：A total of 70 cases of stroke patients with insomnia in our hospital were selected and randomly divided into the experimental group and the control group.Patients in the experimental group were treated by Guipi Decoction and auricular beans therapy and patients in the control group were treated by Guipi Decoction（subtract treatment） for 4 weeks.The Pittsburgh sleep quality index（PSQI） score and serum TNF-α levels of two groups were compared.Results：The effective rate of the experimental group was 91.43%（32/35） and that of the control group was71.43%（25/35） and the difference was statistically significant,P〈0.05.The indexes of PSQI score and total score of two groups after treatment were significantly lower than those before treatment and the difference was statistically significant,P〈0.05.The sleep quality,sleep time,daytime dysfunction and total score in the experimental group were decreased significantly than those in the control group and the difference was statistically significant,P〈0.05.The serum TNF-α levels of two groups significantly were increased after treatment while the experimental group＇s increased more significantly and the difference was statistically significant,P〈0.05.The level of PSQI score and serum TNF-α level showed obvious negative correlation.The patients of two groups had no adverse reaction.Conclusion： The application of Guipi Decoction and auricular beans therapy can obviously improve the clinical effect of patients with post-stroke insomnia and the quality of sleep.The mechanism may be related to its regulation of the level of serum TNF-α.
出处
《中华中医药学刊》
CAS
北大核心
2016年第12期3038-3040,共3页
Chinese Archives of Traditional Chinese Medicine
基金
温州市科技局项目(Y20140529)
关键词
卒中后失眠
归脾汤
耳穴埋豆
临床疗效
血清TNF-Α
post-stroke insomnia
Guipi Decoction
auricular beans therapy
clinical curative effect
serum TNF-α
