摘要
目的:观察去骨瓣减压术联合颞肌贴敷治疗对脑梗死患者免疫功能及血清炎症因子的变化。方法:选取我科收治的脑梗死患者96例,依据治疗方案不同分为观察组及对照组,观察组患者行去骨瓣减压术联合颞肌贴敷治疗,对照组行保守治疗,对比两组治疗前后免疫功能及血清炎症因子指标的变化。结果:两组治疗后1、3dIgG、IgA、IgM水平及CD3^+、CD4^+、CD8^+比例均明显低于术前(P<0.05);观察组治疗后1、3dIgG、IgA、IgM水平及CD3^+、CD4^+、CD8^+比例均显著高于对照组(P<0.05);观察组治疗后各项血清炎症因子水平较治疗前明显下降(P<0.05);观察组治疗后各时间点S100β蛋白、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、高敏C反应蛋白(hs-CRP)含量均显著低于对照组(P<0.05)。结论:采用去骨瓣减压术联合颞肌贴敷疗法能有效降低脑梗死患者机体炎症反应,促进免疫功能恢复。
Objective： To observe the effect of decompressive the immunological function and inflammatory cytokines in patients craniectomy in combined with temporal muscle sticking on with cerebral infarction. Methods： A total of 96 patients with cerebral infarction who were admitted in our hospital were included in the study and divided into the observation group and the control group according to different treatment protocols. The patients in the observation group were given decompressive craniectomy in combined with temporal muscle sticking, while the patients in the control group were given the conservative treatment. The changes of immunological function and serum inflammatory cytokines indicators before and after treatment in the two groups were compared. Results： IgG, IgA, IgM, CD3＋ , CD4＋ , and CD8＋ 1 and 3 d after treatment in the two groups were significantly reduced when compared with before operation （P〈0.05）. IgG, IgA, IgM, CD3＋ , CD4＋ , and CD8＋ 1 and 3 d after treatment in the observation group were significantly higher than those in the control group （P〈0.05）. The levels ofvarious serum inflammatory cytokines after treatment in the observation group were significantly reduced when compared with before treatment （P〈0.05）. $10017, IL-6, TNF-α, ET-1, and hs-CRP contents at each timing point in the observation group were significantly lower than those in the control group （P〈0.05）. Conclusions： The decompressive craniectomy in combined with temporal muscle sticking can effectively reduce the inflammatory reaction in patients with cerebral infarction, and promote the recovery of immunological function.
出处
《海南医学院学报》
CAS
2016年第24期3077-3079,共3页
Journal of Hainan Medical University
基金
重庆涪陵科研课题计划(FLXJ 2012ABB1113)~~
关键词
脑梗死
去骨瓣减压术
颞肌贴敷
免疫功能
炎症因子
Cerebral infarction
Decompressive craniectomy
Temporal muscle stieking
Immunological function
In- flammatory cytokine
