摘要
目的 观察前列地尔联合多巴酚丁胺对慢性肺心病肺动脉高压致心力衰竭的效果。方法 选取2015年12月~2016年2月广东省佛山市高明区人民医院收治的60例慢性肺心病肺动脉高压致心力衰竭患者,采用随机数字表法将其分为观察组和对照组。两组患者均予以同样的基础治疗,对照组加用前列地尔,观察组则予以前列地尔联合多巴酚丁胺。观察比较两组患者的治疗效果、临床症状消失时间以及B型利钠肽（BNP）、肺动脉压、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、第1秒用力呼气量（FEV1）、FEV1占用力肺活量的百分比（FEV1/FVC）水平。结果 观察组总有效率为90.00%,明显高于对照组（73.33%）,差异有统计学意义（P〈0.05）。观察组咳嗽、水肿、发绀、啰音消失时间以及痰液恢复时间均明显短于对照组,差异均有统计学意义（P〈0.05）。治疗后,观察组PaO2、PaCO2、BNP、肺动脉压、FEV1、FEV1/FVC水平均明显优于治疗前和对照组治疗后,差异均有统计学意义（P〈0.05）。结论 前列地尔联合多巴酚丁胺治疗慢性肺心病肺动脉高压致心力衰竭的效果确切,既能有效控制肺动脉高压,又可改善心功能,值得推广应用。
Objective To observe the effects of Alprostadil combined with Dobutamine on the heart failure induced by chronic pulmonary heart disease and pulmonary hypertension. Methods Sixty patients with heart failure induced by chronic pulmonary heart disease and pulmonary hypertension admitted to Gaoming People＇s Hospital of Foshan City from December 2015 to February 2016 were selected and randomly divided into observation group and control group by random number table. Both groups were treated with same basic treatment. The control group was treated with Alprostadil, the observation group was treated with Alprostadil combined with Dobutamine. The therapeutic effect, disappeared time of clinical symptoms and the levels of B type natriuretic peptide （BNP）, pulmonary arterial pressure, arterial partial pressure of oxygen （PaO2）, arterial partial pressure of carbon dioxide （PaCO2）, forced expiratory volume at the first second （FEV1）, the percentage of FEV1 accounted for forced vital capacity （FEV1/FVC） between the two groups were observed and compared. Results The total effective rate of observation group was 90.00%, which was higher than that of control group （73.33%）, the difference was statistically significant （P 〈 0.05）. The disappeared time of cough, edema, cyanosis, rale and the recovery time of sputum in the observation group were all shorter than those of control group, the differences were all statistically significant （P 〈 0.05）. After treatment, the levels of PaO2, PaCO2, BNP, pulmonary arterial pressure, FEV1, FEV1/FVC in the observation group were all better than those before treatment and control group after treatment, the differences were all statistically significant （P 〈 0.05）. Conclusion Alprostadil combined with Dobutamine in the treatment of heart failure induced by chronic pulmonary heart disease and pulmonary hypertension has a definite effect, which can not only control the pulmonary arterial pressure effectively, but also improve the cardiac function, which
出处
《中国医药导报》
CAS
2016年第33期133-136,共4页
China Medical Herald
基金
广东省佛山市卫生和计生局医学科研课题(20160326)
关键词
慢性肺心病
肺动脉高压
心力衰竭
前列地尔
多巴酚丁胺
Chronic pulmonary heart disease
Pulmonary hypertension
Heart failure
Alprostadil
Dobutamine
