摘要
目的:比较"调任通督针刺法"与口服克罗米芬治疗多囊卵巢综合征(PCOS)不孕症的临床疗效差异。方法:将100例PCOS不孕症患者随机分为观察组和对照组,每组50例。观察组予"调任通督针刺法",主穴取中脘、关元、气海、中极、命门、腰阳关、腰俞,治疗于月经结束后开始,隔日治疗1次,治疗4次后行B超检测卵泡,待卵泡检测长至18mm及以上改为每日针刺1次至卵泡排出后停止针刺治疗。对照组于月经周期第5d开始口服克罗米芬,每日50mg,连服5d。两组疗程均为3个月经周期。观察月经周期、子宫内膜厚度、子宫内膜类型(A、B、C型)、宫颈黏液评分、双向型基础体温(BBT)例数、排卵例数、妊娠例数;检测治疗前后血清促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)、泌乳素(PRL)、孕酮(P)和睾酮(T)水平。结果:治疗后两组月经周期均有缩短(均P<0.05),子宫内膜厚度增加和宫颈黏液评分增高(P<0.05,P<0.01),且观察组内膜厚度和宫颈黏液评分提高较对照组更为显著(均P<0.01);两组A型子宫内膜所占比例较治疗前增多(均P<0.05),且观察组A型子宫内膜人数多于对照组(P<0.05);观察组排卵率为88.0%(44/50),优于对照组的70.0%(35/50,P<0.05);治疗后两组血清LH水平均比治疗前降(均P<0.05,P<0.01),且观察组低于对照组(P<0.05)。结论:"调任通督针刺法"能促使PCOS患者月经周期恢复正常,增加子宫内膜厚度,促进卵泡发育成熟,还能有效降低血清LH水平,改善卵巢功能,有效提高排卵率,疗效优于口服克罗米芬。
Objective To compare clinical efficacy differences between＂regulating conception-governor vessel＇＂ acupuncture method and clomiphene for infertility of polycystic ovarian syndrome （PCOS）. Methods One hundred patients of PCOS were randomly assigned into an observation group and a control group, 50 cases in each one. The patients in the observation group were treated with＂ regulating Conception-Governor Vessel＂ acupuncture method at Zhongwan （CV 12）, Guanyuan （CV 4）, Qihai （CV 6）, Zhongji （CV 3）, Mingmen （G-V 4）, Yaoyangguan （GV 3） and Yaoshu （GV 2）. The acupuncture treatment started at the end of menstruation, once every other day; after four treatments, the follicle was tested with B ultrasound; when follicle was longer than 18 mm or above, the acupuncture treatment was given once a day until follicle was discharged and acupuncture treatment finished. The patients in the control group were treated with oral administration of clomiphene from 5 days into menstruation, 50 mg per day for 5 consecutive days. Both groups were treated for three menstruation cycle. The menstrual cy- cles, endometrial thickness, endometrium types （A, B and C）, cervical mucus scores, basal body temperature （BBT）, cases of ovulation, cases of pregnancy were observed. The levels of follicle stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, prolactin （PRL）, progesterone （P） and testosterone （T） in serum were detected before and after the treatment. Results After the treatment, the menstrual cycles were shortened （both P〈O. 05）,the endometrial thickness and cervical mucus scores were increased in the two groups （P〈0.05, P〈0.01）; the improvement of endometrial thickness and cervical mucus score in the observation group were higher than those in the control group （both P〈0.01）. The percentages of type-A endometrium in both groups were higher than those before the treatment （both P〈0.05）; the number of type-A endometrium in the o
出处
《中国针灸》
CAS
CSCD
北大核心
2016年第12期1237-1241,共5页
Chinese Acupuncture & Moxibustion
基金
2014广东省中医药局资助项目:20141252
关键词
多囊卵巢综合征
针刺疗法
调任通督
随机对照临床试验
polycystic ovarian syndrome （PCOS）
acupuncture
regulating conception-governor vessel
RCT
