摘要
目的：探讨基于卡培他滨的放疗方案治疗消化道肿瘤的临床疗效及不良反应发生情况。方法回顾性分析2011年7月至2015年6月行放射治疗的40例消化道肿瘤患者的临床资料，将其随机以双盲法分为研究组和对照组，每组20例。两组均给予常规放射治疗，研究组在此基础上加服卡培他滨用药。评价两组临床疗效及1年期、3年期生存率，记录不良反应发生情况。结果研究组有效率和疾病控制率分别为55.0%和85.0%，均高于对照组（35.0%和65.0%，P〈0.05）。研究组疾病进展时间和3年期生存率优于对照组，差异有统计学意义（P〈0.05），但两组化疗后不良反应发生率比较差异未见统计学意义（P〉0.05）。结论对于消化道肿瘤患者在常规放疗基础上联用卡培他滨能提高3年期生存率，延长疾病进展时间，且对近期生存率影响不大。与单纯放疗相比二者有效率和不良反应差异未见统计学意义，建议临床可积极尝试卡培他滨联合放疗的方案，以提高远期生存率。
Objective To evaluate the clinical efficacy and side effects of radiotherapy based on capecitabine on gastrointestinal tumor. Methods The clinical data of 40 patients with gastrointestinal tumor receiving radiation therapy from July 2011 to June 2015 were retrospectively analyzed,they were randomly divided into study group and control group according to double-blind,with 20 cases in each group. Both groups were given conventional radiation therapy,the study group received service capecit-abine treatment based on this. The clinical efficacy of the two groups were evaluated and the 1-year, 3-year survival rate,incidence of toxicity were recorded. Results The efficiency and disease control rate＆amp;nbsp;were 55. 0% and 85. 0% in study group,which were higher than those in the control group（35. 0% and 65. 0% ,P〈 0. 05）. TTP and 3-year survival rate in study group were better than those in the control group,the differences were significant（P〈 0. 05）,but the overall incidence of adverse reactions after chemotherapy had no significant difference between the two groups（ P〉 0. 05）. Conclusions For patients with gastrointestinal tumor,on the basis of conventional radiotherapy in combination with capecit-abine can improve the 3-year survival rate,prolong time to disease progression,but has little effect on the recent survival rate. Compared with radiotherapy alone,effectiveness and adverse reactions had no signif-icant difference. In clinical recommendations,capecitabine combined with radiotherapy can be actively tried to improve long-term survival rate.
出处
《中国实用医刊》
2016年第22期35-37,共3页
Chinese Journal of Practical Medicine
关键词
卡培他滨
放疗
消化道肿瘤
生存率
不良反应
Capecitabine
Radiotherapy
Gastrointestinal tumor
Survival rate
Adverse reaction
