摘要
目的了解四川省布拖县重点地区艾滋病病毒(HIV)感染儿童抗病毒治疗情况,为提高治疗效果提供建议。方法 2015年1~3月,对现住址为布拖县重点乡镇感染艾滋病儿童的监护人进行一对一的问卷调查,内容包括儿童一般人口学特征,监护人对抗病毒治疗的认知,以及儿童抗病毒治疗现状等,并从《艾滋病综合防治信息系统》收集CD4^+T细胞计数与病毒载量检测等相关信息。用SPSS 19.0软件进行频率描述,配对t检验和秩和检验等统计分析,P<0.05为差异有统计学意义。结果接受调查的121名儿童中有68人(56.20%)正在接受抗病毒治疗,开始治疗时平均年龄(8.12±2.32)岁,平均已治疗(1.92±1.09)年。在治儿童第一次CD4^+T细胞计数水平显著高于基线(P=0.034);两次病毒载量检测结果差异无统计学意义(P=0.533)。有56人(46.28%)不知道需要每天坚持服药;19人(15.70%)不知道何时应开始治疗。结论布拖县感染艾滋病儿童疾病负担重,其监护人对抗病毒治疗认知存在不足;儿童抗病毒治疗覆盖率不高,虽然早期CD4^+T细胞计数明显升高,但中长期效果尚不显著;提示应加强儿童治疗医务人员技术培训,开展家庭内长期支持儿童抗病毒治疗宣传,以提高儿童长期抗病毒治疗效果。
Objective To understand the status of the pediatric free antiretroviral therapy（ART）in HIV high epidemic areas of Sichuan and to provide therapeutic suggestions. Methods A questionnaire survey was conducted among guardians of HIV positive children in HIV high epidemic towns of Butuo from Jan to Mar 2015,including children′s demographic characteristics,guardian′s awareness on ART and current performance of ART.CD4^＋ T cell count and viral load data were retrieved from HIV/AIDS information system for Comprehensive Prevention and Control.The comparative t-test and the rank test were conducted by SPSS 19.0 package. Results Among 121 HIV positive children surveyed,only 56.20% had ongoing HIV ART,the average age of children was（8.12±2.32）years old when ART was initiated,and the average years of being treated was（1.92±1.09）.The CD4^＋ T cell counts after the ART was significantly higher than that in baseline（P=0.034）,however,the viral load did not change a lot（P=0.533）.46.28% of subjects did not know of taking medicine every day and 15.70% had no idea of when to start the treatment. Conclusions Butuo,HIV disease burden is high among HIV positive children and guardians were lack of the cognition to ART with the low coverage rate of ART.Even though.CD4^＋ T cell counts increase after ART,the effect is not strong enough for the lone run.Therefore,it is suggested that pediatric ART technical supports should be provided to local pediatricians and family with HIV positive kids should support their treatment.
出处
《中国预防医学杂志》
CAS
2016年第11期805-808,共4页
Chinese Preventive Medicine
基金
国家十二五国家科技重大专项(2013ZX10004-908)
关键词
艾滋病
儿童
抗病毒治疗
HIV/AIDS
Children
Antiretroviral therapy
