摘要
目的通过测定妊娠期糖尿病（GDM）哺乳期妇女初乳和90d成熟乳中脂联素（Adiponectin）、Ape-lin、婴儿血管内皮生长因子．1（VEGF—R1）受体的水平，探讨母体血脂、血糖代谢异常与儿童体质量的关系。方法本研究采用前瞻性平行对照试验，收集2014年12月至2015年6月分娩的GDM产妇及其新生儿为GDM组（20对）；另外选取产科同期单胎足月分娩，且无妊娠合并症的健康产妇及其新生儿为对照组（25对）。检测各组母亲初乳及成熟乳中Adiponectin、Apelin水平的变化情况，比较新生儿脐血中的VEGF-R1水平，并且分析Adiponec—tin、Apelin、VEGF．R1与儿童体质量的关系。结果①GDM组母乳中，无论是初乳还是成熟乳中Adiponectin水平均远低于对照组（P〈0．05），但新生儿脐血中VEGF—R1水平却高于对照组（P〈0．05）；初乳和成熟乳中Apelin水平比较差异未见统计学意义（P〉0．05）。②GDM哺乳期妇女母乳中Adiponectin和新生儿脐血中VEGF-R1均与新生儿体质量呈正相关。但GDM哺乳期妇女母乳中Apelin与新生儿出生体质量不相关。结论在糖代谢异常的孕妇中，孕前及产前的肥胖程度对其儿童体质量有很大影响，其与母亲乳汁中的Adiponectin、Apelin及婴儿自身VEGF-R1的水平均存在密切关系。
Objective Through the determination of pregnancy gestational diabetes mellitus （GDM） lactating women eolostrum and 90 day mature milk adiponeetin （Adiponectin）, Apelin, baby vascular endothelial growth factor-1 （ VEGF-R1 ） receptor levels, to detect the correlation between mater- nal serum levels of lipid and glucose metabolism abnormality arid children＇ s body mass. Methods Pro- spective randomized controlled trims were used from December 2014 to June 2015, GDM pregnant women and their newborns for GDM group （20 pairs） were selected; in addition to select obstetrical period sin- gleton term delivery, and no pregnancy complications of healthy pregnant women and newborns as control group （n = 25 ）. The changes of Adiponectin and apelin levels in maternal colostrum and mature milk were detected, and the levels of VEGF-R1 in umbilical cord blood were compared, and the correlation between Adiponeetin, apelin, VEGF-R1 and the quality of children＇ s body was analyzed. Results In GDM group , the Adiponectin levels in colostrum and mature milk were significant lower than those of the control group （P 〈 0. 05）, but the levels in cord blood of neonate VEGF-R1 was higher than in that the control group （P 〈 0. 05 ） ; Apelin levels in colostrum and mature milk between the two groups has no significant difference （P 〉 0. 05）. Adiponectin and neonatal umbilical cord blood VEGF-R1 were positively correlated with neonatal body mass in GDM breast feeding women. However, Apelin was not related to the quality of newborn babies in the breast milk of GDM during lactation. Conclusions In pregnant women with abnormal glucose metabolism, obesity in pregnancy and prenatal has remarkable effects on their children＇ s body mass, and its level is closely correlated with Adiponectin, apelin in the mother＇ s milk and baby＇ s own VEGF-R1.
出处
《中国实用医刊》
2016年第21期103-105,共3页
Chinese Journal of Practical Medicine
