无创呼吸机治疗慢性阻塞性肺疾病合并慢性肺源性心脏病疗效观察被引量：7

Effect of Noninvasive Ventilator Treatment in the Patients with Chronic Obstructive Pulmonary Disease Combined with Chronic Cor Pulmonale

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摘要目的：分析应用无创呼吸机治疗慢性阻塞性肺疾病（慢阻肺）合并肺源性心脏病患者的临床效果.方法：纳入我院收治的慢阻肺合并肺源性心脏病患者72例,均于2013年7月～ 2015年9月期间就诊,按入院顺序编号后随机分组,即对照组（常规治疗）和观察组（常规疗法联合无创呼吸机治疗）各36例,对比两组的治疗效果和相关指标水平变化情况.结果：观察组的PaCO2、HCO3-、肺动脉压力分别为（46.58 ＆#177;7.92） mmHg、（31.83＆#177;5.29） mmol/L、（41.48＆#177;4.59） mmHg,均低于对照组,且观察组的PO2、FEV1、FEV1/FVC分别为（67.81 ＆#177;6.49） mmHg、（75.38＆#177;3.10）％、（56.27＆#177;4.81）％,较对照组更高,组间对比差异显著（t=15.39,12.90,13.28,13.78,15.98,15.28;P＜0.05）;且治疗后观察组的Nt-proBNP水平较对照组更低（t=13.67,P＜0.05）.结论：应用无创呼吸机对慢阻肺合并肺源性心脏病患者予以治疗,能够在改善患者呼吸功能的同时,促进心功能恢复,降低心衰发生风险,临床应用价值高. OBJECTIVE： To analyze the effect of noninvasive ventilator in the patients with chronic obstructive pulmonary disease （COPD） combined with cor pulmonale. METHODS： 72 patients with COPD combined with cor pulmonale from July 2013 to Septem- ber 2015 in our hospital were divided into the control group （n = 36, routine treatment） and observation group （n = 36, conventional therapy in combination with noninvasive ventilator therapy）. Treatment effect arid ralated index level changes were compared in two groups. RESULTS： PaCO2 （31.83 ±5.29） mmol/L, HCO3 - （41.48±4. 59） mmHg and pulmonary artery pressure （46. 58 ±7.92） mmHg in the observation group were lower than those in the control group. PO2 （75.38± 3.10）%, FEV1 （56.27± 4. 81 ）% and FEVJFVC （67.81±6.49） mmHg in the observation group were higher than those in the control group. There was the significant difference between two groups （ P 〈 0.05 ）. After treatment in the observation group Nt - pro BNP levels were lower than those in the control group （P 〈 O. 05 ）. CONCLUSION ： The application of noninvasive ventilator treatment in the patients with COPD combmed with cot pulmonale can improve the patients＇ respiratory function, promote the heart function recovery, and reduce the risk of developing heart failure.

作者赵晓秋陶赟臻武俊华柳江红梁菲菲 Zhao Xiaoqiu Tao Yunzhen Wu Junhua Liu Jianghong Liang Feifei(Department of Respiratory Medicine, the First Hospital of Zhengjiakou, Zhangiiakou 075000, China Department of Geriatries, the Yirst Hospital of Zhangjiakou, Zhangjiakou 075000, China)

机构地区河北省张家口市第一医院呼吸内科河北省张家口市第一医院老年病科

出处《国际老年医学杂志》 2016年第6期258-260,共3页 International Journal of Geriatrics

基金张家口市科学技术和地震局2015年度市级科技计划自筹经费项目（1521031D）

关键词无创呼吸机慢性阻塞性肺疾病慢性肺源性心脏病临床疗效 Noninvasive ventilator Chronic obstructive pulmonary disease Chronic cor pelmonale Clinical curative effect

分类号 R541.5 [医药卫生—心血管疾病]